How an Early or Late Transition State Impacts the Stereoselectivity of Tetrahydropyran Formation by Intramolecular oxa-Michael Addition

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00750D, PaperDaniel Csokas, Annabel Xuan Ying Ho, Raghunath Ramabhadran, Roderick Wayland Bates The intramolecular oxa-Michael addition giving tetrahydropyrans has been examined experimentally using both acidic and basic catalysis. With acidic catalysis, the diequatorial product is exclusively obtained in a kinetically controlled reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research