Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.

Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.
Cell Stem Cell. 2019 Jun 06;24(6):835-836
Authors: Manley WF, Anderson SA
Abstract
Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity for the development of novel therapeutics.
PMID: 31173710 [PubMed - in process]

Source: Cell Stem Cell - June 5, 2019 Category: Stem Cells Authors: Manley WF, Anderson SA Tags: Cell Stem Cell Source Type: research