Effects of gossypol on apoptosis ‑related gene expression in racially distinct triple‑negative breast cancer cells.

In conclusion, the data obtained in this study provide a molecular understanding of the GOSS‑induced apoptosis effect and suggest the importance of this polyphenol compound targeted towards TNBC treatment, particularly in African‑American women. PMID: 31173249 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Publication date: Available online 13 July 2019Source: Seminars in Cancer BiologyAuthor(s): Zoi Piperigkou, Nikos K. KaramanosAbstractThe biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and extracellular matrix (ECM) macromolecules are principal mediators of ECM remodeling in the tumor and the adjacent stroma. In breast cancer, ERs are critical biomarkers as their expression in breast tumor determines the disease-free survival, yet g...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Correction to "Enzymatic stimuli-responsive methotrexate-conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition". J Biomed Mater Res A. 2019 Sep;107(9):2115 Authors: PMID: 31301222 [PubMed - in process]
Source: Biomed Res - Category: Research Tags: J Biomed Mater Res A Source Type: research
(Natural News) Breast augmentation is the most common type of cosmetic surgery in the U.S., with more than 300,000 women getting breast implants a year. Most women usually get breast implants for aesthetic purposes, while the rest see it as an option following a breast cancer surgery. In a recent statement, however, the Food and Drug Administration...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
The internet is awash with ads for costly but bogus treatments – and claims that scientists are suppressing a cure for the diseaseFor Eileen O ’Sullivan, being diagnosed with breast cancer in 2013 was the catalyst for a deluge of distinctly unscientific and frequently dangerous advice. An investment manager with a analytical mind, she began seeking information to better understand her potentially life-altering condition. But from the mom ent Eileen starting searching online, misinformation was unavoidable: “This is when all the suggestions start rolling in,” she says. “Before diagnosis, I had ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Cancer Health Society Cancer research Medical research Internet Technology Facebook Social networking Media Crowdfunding Source Type: news
Conclusion: The conclusion of this review contributes to the development of a more comprehensive and objective instruments based on the deficiencies of the existing studies. PMID: 31298055 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
This study was to evaluate the efficacy of the three methods in SLNB for breast cancer, and to analyze its influencing factors. Methods: One hundred eighty patients with early breast cancer were recruited and randomly divided into 3 groups. Each group comprising of 60 patients with SLNB using ICG + MB, MB, and CN, respectively. Then the 3 groups were compared in detection rate, mean number of SLNs, and the detection rates and number of metastatic sentinel lymph nodes (SLNs). Results: The detection rate of SLNs was 100% (60 of 60) in ICG + MB group, 96.7% (58 of 60), and 98.3% (59 of 60) in MB and CN group, respecti...
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Publication date: Available online 13 July 2019Source: European Journal of Surgical OncologyAuthor(s): Rosa Di Micco, Veronica Zuber, Enrico Fiacco, Federica Carriero, M. Ilaria Gattuso, Ludovica Nazzaro, Pietro Panizza, Luigi Gianolli, Carla Canevari, Nadia Di Muzio, Marcella Pasetti, Isabella Sassi, Milvia Zambetti, Oreste D. Gentilini
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionAlthough the majority of screen-detected cancers are equal to more conspicuous on SM when compared to FFDM, calcifications and asymmetries
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusion: Early stage breast cancer patients were evaluated by a surgeon, radiation oncologist and medical oncologist less than 75% of the time. Enhanced coordination of care and navigation programs may improve the quality of care delivered. PMID: 31296072 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
In this study, we successfully synthesized PEG-Hb nanoparticles loading with PTX based on previously well-established acid-denatured method. PEG-Hb-PTX NPs showed enhanced cellular uptake and great cellular inhibition ability in vitro. Moreover, our animal study showed that PEGylated NPs greatly accumulated in tumor tissues and exhibited excellent anticancer activity in vivo. We found that PEG-Hb-PTX NPs possess a better in vivo antitumor effect than the commercially available Taxol® formulation. We believe that PEG-Hb has great potential as an efficient drug delivery system for further clinic study. PMID: 31293178...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
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