Longitudinal brain changes in MDD during emotional encoding: effects of presence and persistence of symptomatology.

CONCLUSION: Using a longitudinal within-subjects design, we showed that hippocampal-amygdalar activation during emotional memory formation is related to depressive symptom severity but not persistence (i.e. time spent with depression or 'load'), suggesting functional activation patterns in depression are not subject to functional 'scarring' although this hypothesis awaits future replication.
PMID: 31169102 [PubMed - as supplied by publisher]

Source: Psychological Medicine - June 5, 2019 Category: Psychiatry Authors: Ai H, Opmeer EM, Marsman JC, Veltman DJ, van der Wee NJA, Aleman A, van Tol MJ Tags: Psychol Med Source Type: research