Cold Urticaria: Clinical Features and Natural Course in a Tropical Country.

CONCLUSIONS: The rate of anaphylaxis in patients with ColdU in a tropical country was lower than those reported by other studies conducted intemperate climates. On the other hand, the number of female patients, mean age at symptom onset, atopy rate, rate of concomitant chronic spontaneous urticaria and mean CTT were higher. PMID: 31172722 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

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AbstractBackgroundPlatelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH) has been shown to be associated with anaphylaxis, asthma, and peanut allergy. The purpose of this study was to investigate relationships among clinical parameters, including urticaria severity and treatment responsiveness, and PAF and PAF-AH levels in sera from patients with chronic spontaneous urticaria (CSU).MethodsSerum PAF and PAF-AH levels were measured by enz...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Purpose of review Nonsteroidal anti-inflammatory drug (NSAID) is one of the most frequently prescribed medications in the medical field, and hypersensitivity to NSAID is a common adverse drug reaction encountered. However, NSAID hypersensitivity presents a variety of symptoms caused by diverse pharmacological and immunological mechanisms. Recent findings Owing to the heterogeneity of the disease, a new concept for the classification of NSAID hypersensitivity has recently been proposed to diagnose and manage NSAID hypersensitivity for personalized treatment. Acute and delayed reactions were distinguished in this classi...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research
Allergy to galactose-alpha-1,3-galactose (alpha-gal) presents as an IgE-mediated, yet delayed-onset hypersensitivity reaction to non-primate mammalian meat.1 Alpha-gal sensitization develops after tick bite exposure.1-3 The lone-star tick (Amblyomma americanum) represents the North American vector, spanning a relatively vast southeast, mid-west, and northeast geographic distribution.4 Allergic manifestations include urticaria/angioedema, abdominal pain/diarrhea, or anaphylaxis, occurring approximately 3-6 hours after ingestion.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Recently, new diagnostic tools and therapeutic agents have significantly increased the survival rate of cancer patients compared to that in the past. As the number of cancer survivors exposed to multiple courses of chemotherapy increases, more patients become sensitized to chemotherapeutic agents and suffer from hypersensitivity reactions (HSRs).1-3 HSRs to chemotherapeutic agents range from mild cutaneous urticaria to severe reactions, such as life-threatening anaphylaxis, and even death.4 Most HSRs are unpredictable, such that they threaten the safety of patients; moreover, they can be uncontrollable, and severe HSRs lim...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Thank you to you and your colleagues for your valuable and thoughtful paper, “Management of anaphylaxis and allergies in patients with long QT syndrome.”1 Because high-dose antihistamine therapy for chronic urticaria has become increasingly common, we have been considering what (if any) precautions should be taken before prescribing that to a patient, including such seem ingly “routine” measures (not routine in an allergist's office), such as getting an electrocardiogram on anyone getting an antihistamine, which is surely a lot of patients.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
AbstractPurpose of ReviewAn unconfirmed penicillin allergy is known to confer significant risk to patients. Only a small minority of patients labeled with penicillin allergy will be confirmed to be hypersensitive with the current reference standard test, an oral amoxicillin therapeutic dose challenge. Skin testing has been recommended prior to oral challenges to reduce the risk of severe acute challenge reactions. The rate of severe acute anaphylactic reactions with oral amoxicillin is currently extremely low. Unfortunately, penicillin skin testing, as commonly performed, has a high rate of false positive results.Recent Fi...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Aerobic exercises can precipitate inducible urticarias. Cholinergic urticaria and exercise-induced anaphylaxis are good examples of these triggers1-2. The same can happen in patients with delayed pressure urticaria when areas of the body are compressed during exercises3. To our knowledge, sexual intercourse has not been documented for triggering inducible urticarias. We are presenting two cases of inducible urticaria precipitated by sexual intercourse: exercise-induced anaphylaxis and delayed pressure urticaria.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
This study — known as the Learning Early About Peanut or LEAP trial — showed that children at high risk of developing peanut allergies who are introduced to peanuts at 4 months to 6 months old had a significantly lower risk of developing a peanut allergy than those who waited until they were 5 years; 1.9% of the kids who had peanuts early developed an allergy, compared with 13.7% of the kids who waited. The LEAP trial formed the basis for Monday’s new recommendations, which encourage the early introduction of peanut products in infants at high risk for allergies. But most babies are not at high risk, and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Food Allergies Source Type: news
Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis, and vasculitis)1. Hypersensitivity reactions to rituximab can range from type I IgE-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis), to cytokine-mediated reaction (fevers, chills, rigors), or a mix of both, thus limiting the use of rituximab as first line therapy for many cases. Desensitization is a new therapeutic approach which can be performed with rituximab to offset these reactions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis and vasculitis).1 Hypersensitivity reactions to rituximab can range from type I immunoglobulin E (IgE)-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis) to cytokine-mediated reaction (fevers, chills, rigors) or a mix of both, thus limiting the use of rituximab as first-line therapy for many cases. Desensitization is a new therapeutic approach that can be performed with rituximab to offset these reactions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
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