Pathology and bronchoalveolar lavage fluid cellular and oxidative stress changes in canine pneumonia in Nigeria

This study is on the pathology and bronchoalveolar cellular and oxidative stress changes in naturally occurring canine pneumonia in Nigeria. The dogs used were collected from cases submitted for necropsy in the institutional Department of Veterinary Pathology. Gross examination, bronchoalveolar lavage (BAL) cytology, oxidative biochemical assay of BAL fluid (BALf) supernatant and histology of sections from all the lung lobes were done using standard procedures. Grossly, 22 (31%) were normal while 48 (69%) were congested, haemorrhagic and/or pneumonic out of the 70 canine lungs examined. Microscopically, there were pulmonary congestion (4%), pulmonary oedema (20%), pulmonary haemorrhages (7%), atelectasis (4%), interstitial pneumonia (10%), bronchointerstitial pneumonia (14%) and bronchopneumonia (9%). The BALf cytology of pneumonic lungs showed increases in neutrophils, alveolar macrophages, lymphocytes and haemosiderophages including free and phagocytosed bacteria, and fungal hyphae. Glutathione peroxidase (GPx) and glutathione transferase (GST) activities increased in congested and bronchointerstitial pneumonic lungs but were reduced in other pneumonic lungs. The superoxide dismutase (SOD) activity was significantly reduced in the pneumonic canine lungs. Hydrogen peroxide generation increased in congestion and oedema, bronchopneumonia and bronchointerstitial pneumonia. Malondialdehyde (MDA) level increased in other congested and pneumonic lungs. There was also significant p...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

Related Links:

We present the case of a 44-year-old man, a pigeon breeder admitted to hospital with a pruritic purpuric eruption and lower limb paresthesia, dyspnea on exertion, polymyalgia rheumatica, mixed polyarthralgias. Based on the clinical, paraclinical and laboratory investigations (electroneuromyography, plethysmography, computed tomography scan, musculocutaneous biopsy, current laboratory tests and immunoassays), the main diagnoses of extrinsic allergic alveolitis and leukocytoclastic vasculitis were determined. The patient underwent treatment with corticosteroids with a favorable outcome, but which becomes aggravated by the oc...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Publication date: 15 November 2019Source: Journal of Molecular Structure, Volume 1196Author(s): A.M. Ismail, A.A. Menazea, Hoda A. Kabary, A.E. El-Sherbiny, A. SamyAbstractThe influence of different calcination temperatures on the molecular structure, optical, morphological and antimicrobial activity were investigated for Zinc Oxide nanoparticles (ZnO NPs) synthesized using green sol-gel method. The prepared ZnO NPs are calcined at 70 °C, 300 °C, 400 °C and 800 °C. The effect of different calcinations temperature on the characterization of the prepared samples were studied using X-ray Diffraction (X...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Rationale: Esophageal duplication cyst (EDC) is a rare developmental aberration originated from the embryonic foregut. It may remain asymptomatic but produce local mass effect on surrounding organs if rapid enlarges. EDC may sometimes accompany with other congenital malformations. Congenital pulmonary airway malformation (CPAM) is a congenital lung malformation with an unknown chance of developing symptoms. Here we report a rare case of esophageal duplication cyst with type 2 congenital pulmonary airway malformation (CPAM). Patient concerns: A 16-month old boy with a prenatal diagnosis of type 2 CPAM presented progres...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Rationale: Propylthiouracil (PTU) is a common antithyroid drug which can treat hyperthyroidism effectively. PTU is, however, associated to multiple adverse effects. In rare case, PTU can cause interstitial pneumonia. Patient concerns: A 40-year-old woman presented with dyspnea and was diagnosed with pulmonary infection at the first time. After the treatment with moxifloxacin, her symptoms still got worse. Diagnosis: The lung tissues biopsy confirmed the diagnosis of organizing pneumonia (OP) and the administration of PTU suggested the diagnosis of PTU-induced OP. Intervention: Withdrawal of PTU and the administr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is essential to ensure prompt initiation of appropriate treatment and enrolment in clinical trials. According to current international guidelines [1], in the appropriate clinical context the identification of the usual interstitial pneumonia (UIP) pattern on chest high-resolution computed tomography (CT) allows a confident diagnosis of IPF. Patients referred to tertiary centres for suspected interstitial lung disease (ILD) may provide CT images that do not fulfil recommended scanning protocols [1], therefore triggering the execution of another CT. However, the impac...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
CONCLUSION: These results show that levonadifloxacin has an improved bactericidal effect on biofilm-embedded quinolone-resistant S. aureus and meticillin-resistant S. aureus, and that it can be a promising treatment option for such infections. PMID: 31241446 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
ConclusionOP secondary to lung cancer of unknown primary site are rare. When OP patients have lymphadenopathy or poor response to glucocorticoid, a more differential diagnosis should be considered, especially for avoiding the misdiagnosis of a malignancy.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionIn SLE cases, IP primarily occurred in male and elderly patients. In addition to the NSIP pattern, the UIP pattern was evident on HRCT scans of IP-related SLE. The survival of SLE patients was unrelated to IP.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
CONCLUSION: The diagnosis of hypersensitivity pneumonitis should be considered in similar cases. Treatment is based mainly on removing exposure to the causative antigen. PMID: 31202600 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Ethnic value of many known plants are underexploited for medicinal application besides their proven traditional qualities. One such plant known for wound healing is Tridax procumbens. This plant has wound healing property and is commercially unexploited. Silver nanoparticle (Ag-NP) were synthesized using this plant extracts using different solvents (methanol, ethyl acetate and aqueous), which exhibit resonance at 426, 424 and 418 nm, respectively. This plant-mediated Ag-NPs have strong anti-bactericidal activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes, Klebsiella pn...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
More News: African Health | Antidoxidants | Cytology | Nigeria Health | Pathology | PET Scan | Pneumonia | Respiratory Medicine | Study | Veterinary Research