New sequential combinations of non-invasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD

Non-alcoholic fatty liver disease (NAFLD), the liver manifestation of the metabolic syndrome linked to obesity and insulin resistance, affects 25% of the general population both in western and developing countries.1 As in the other causes of chronic liver disease, liver fibrosis is the main determinant of prognosis in NAFLD.2 The risk of liver-related mortality increases from fibrosis stage 2 and is exponentially higher when transitioning to stage F3 (bridging fibrosis) then F4 (cirrhosis).2 Therefore, as recommended by international guidelines, patients with NAFLD should be assessed for the presence of advanced F3/4 fibrosis, because of its prognostic implications.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research