Decreased M1 macrophage polarization in dabigatran-treated Ldlr-deficient mice: Implications for atherosclerosis and adipose tissue inflammation

The non-vitamin K oral anticoagulant dabigatran etexilate (dabigatran) is increasingly prescribed to patients with non-valvular atrial fibrillation and venous thromboembolism. Adipose tissue (AT) inflammation during obesity plays a crucial role in the development of insulin resistance, type II diabetes and atherogenesis. The aim of the present study was to investigate the effects of thrombin inhibition by dabigatran in a combined model of diet-induced obesity and atherosclerosis.

Source: Atherosclerosis - June 6, 2019 Category: Cardiology Authors: Kathrin Feldmann, Maria Grandoch, Christina Kohlmorgen, Birte Valentin, Stephen Gerfer, Nadine Nagy, Sonja Hartwig, Stefan Lehr, Anke C. Fender, Jens W. Fischer Source Type: research