Recent advances in the neural regulation of feeding behavior in adult Drosophila.

Recent advances in the neural regulation of feeding behavior in adult Drosophila.
J Zhejiang Univ Sci B. 2019 Jul;20(7):541-549
Authors: Wang GH, Wang LM
Abstract
The ability to maintain metabolic homeostasis is a key capability critical for the survival and well-being of animals living in constantly changing environments. Metabolic homeostasis depends on neuromodulators, such as biogenic amines, neuropeptides, and hormones, to signal changes in animals' internal metabolic status and to orchestrate their behaviors accordingly. An important example is the regulation of feeding behavior by conserved molecular and cellular mechanisms across the animal kingdom. Its relatively simple brain coupled with well-characterized genetics and behavioral paradigms makes the fruit fly Drosophila melanogaster an excellent model for investigating the neuromodulatory regulation of feeding behavior. In this review we discuss the neuromodulators and neural circuits that integrate the internal physiological status with external sensory cues and modulate feeding behavior in adult fruit flies. Studies show that various specific aspects of feeding behavior are subjected to unique neuromodulatory regulation, which permits fruit flies to maintain metabolic homeostasis effectively.
PMID: 31168968 [PubMed - in process]

Source: J Zhejiang Univ Sci ... - June 8, 2019 Category: Science Authors: Wang GH, Wang LM Tags: J Zhejiang Univ Sci B Source Type: research