Cancers, Vol. 11, Pages 790: Neoadjuvant Pazopanib Treatment in High-Risk Soft Tissue Sarcoma: A Quantitative Dynamic 18F-FDG PET/CT Study of the German Interdisciplinary Sarcoma Group
Cancers, Vol. 11, Pages 790: Neoadjuvant Pazopanib Treatment in High-Risk Soft Tissue Sarcoma: A Quantitative Dynamic 18F-FDG PET/CT Study of the German Interdisciplinary Sarcoma Group
Cancers doi: 10.3390/cancers11060790
Authors:
Christos Sachpekidis
Ioannis Karampinis
Jens Jakob
Bernd Kasper
Kai Nowak
Lothar Pilz
Ulrike Attenberger
Timo Gaiser
Hans-Günter Derigs
Matthias Schwarzbach
Peter Hohenberger
Antonia Dimitrakopoulou-Strauss
Ulrich Ronellenfitsch
The outcome of high-risk soft tissue sarcoma (STS) is poor with radical surgery being the only potentially curative modality. Pazopanib is a multikinase inhibitor approved for the treatment of metastatic STS. Herein, in terms of the German Interdisciplinary Sarcoma Group (GISG-04/NOPASS) trial, we evaluate the potential role of kinetic analysis of fludeoxyglucose F-18 (18F-FDG) data derived from the application of dynamic positron emission tomography/computed tomography (PET/CT) in response assessment to pazopanib of STS patients scheduled for surgical resection. Sixteen STS patients treated with pazopanib as neoadjuvant therapy before surgery were enrolled in the analysis. All patients underwent dynamic PET/CT prior to and after pazopanib treatment. Data analysis consisted of visual (qualitative) analysis of the PET/CT scans, semi-quantitative evaluation based on standardized uptake value (SUV) calculations, and quantitative analysis of the dynamic 18F-FDG PET data, based on two-tissue compa...
Source: Cancers - Category: Cancer & Oncology Authors: Christos Sachpekidis Ioannis Karampinis Jens Jakob Bernd Kasper Kai Nowak Lothar Pilz Ulrike Attenberger Timo Gaiser Hans-G ünter Derigs Matthias Schwarzbach Peter Hohenberger Antonia Dimitrakopoulou-Strauss Ulrich Ronellenfitsch Tags: Article Source Type: research
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