The role of TNF- α in chordoma progression and inflammatory pathways

ConclusionsFrom our data we conclude that TNF- α may serve as a prognostic marker for chordoma progression and that tumor-promoting inflammation may be a major factor in chordoma tumor progression.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 15 November 2019Source: Pharmacological ResearchAuthor(s): Hao Jia, Haixia Peng, Zhaoyuan HouAbstractThe LIM protein Ajuba contains an unstructured proline/glycine-rich preLIM region in the N terminus and conserved tandem LIM motifs in the C terminus. Additionally, Ajuba contains both nuclear export sequences (NES) and nuclear localization sequences (NLS), which enable Ajuba shuttle between the cytoplasm and the nucleus. Thus, Ajuba can act as a versatile scaffold participating in assembly of variety of protein complexes to execute multiple cellular functions including cell adhesion, moti...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 November 2019Source: Pharmacological ResearchAuthor(s): Mingxue Li, Dun Wang, Jianhua He, Lixia Chen, Hua LiAbstractB-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects. Bcl-XL interacts with Beclin 1, a key factor regulating autophagy.Bcl-XL is essential for the survival of neurons and plays protective ro...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsHuMax-IL8 is safe and well-tolerated. Ongoing studies are evaluating the combination of IL-8 blockade and other immunotherapies.Trial registrationNCTN, NCT02536469. Registered 23 August 2015,https://clinicaltrials.gov/ct2/show/NCT02536469?term=NCT02536469&rank=1.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Abstract Previous researches suggested microRNA-140-3p (miR-140-3p) and miR-155-5p as cancer promotor in chordoma. We aimed to investigate the mechanisms of these two miRNAs in chordoma cells. Patient-derived chordoma cell lines were established in vitro. Expressions of miR-140-3p or miR-155-5p were measured by quantitative real-time polymerase chain reaction and their functions were inhibited by antagomir treatment. Malignancy of chordoma cells was assessed by cell viability, proliferation, apoptosis, colony formation and transwell invasion assays as well as western blot evaluating epithelial-to-mesenchymal trans...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
In this study, dysregulated miRNAs were determined in chordoma CSCs and identified their role in chordoma. Dysregulated miRNAs were determined via miRNA microarray and validated through qPCR. miRNAs were transiently transfected to the chordoma cell lines and their roles in proliferation, apoptosis, migration and invasion capacities and stem-like properties were identified. Finally, a relationship between clinicopathological features and dysregulated miRNAs has been evaluated among 21 chordoma patients. CD133+CD15+ cells exhibited CSC phenotype with increased CSC- and Epithelial-Mesenchymal Transition (EMT)-related gene exp...
Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
AbstractChordomas are rare, slowly growing, locally aggressive bone neoplasms that arise from embryonic remnants of the notochord, showing dual epithelial-mesenchymal differentiation. The high plasticity probably is the main reason for the high variety in phenotypes of chordoma, from its high heterogeneity on a cellular level to its subtype variations depending on tissue location, with its potential to develop from an inactive quiescent form to an aggressive cancer with extreme adaptability and resistance to drugs and other treatments. Gene expression profiles of formalin-fixed, paraffin-embedded skull chordoma, spine chor...
Source: Virchows Archiv - Category: Pathology Source Type: research
Authors: Gulluoglu S, Sahin M, Tuysuz EC, Yaltirik CK, Kuskucu A, Ozkan F, Sahin F, Ture U, Bayrak OF Abstract Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemo- and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential, and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. The leukemia inhib...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
INTRODUCTION:Accumulating evidence suggests malignant neoplasms contain a distinct subset of cells that hijack stem cell transcriptional programs to attain tumor initiating and propagating abilities. As such, transcriptional programs coordinating early embryogenesis have recently emerged as oncogenic drivers and potential therapeutic targets. Brachyury, a core T-box transcription factor, plays a vital role during development. Incidentally, Brachyury is overexpressed in several cancers including primary and metastatic brain tumors where it promotes growth, confers resistance to chemo- and radiotherapy, drives metastatic pot...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: CELL SIGNALING AND SIGNALING PATHWAYS Source Type: research
Glioblastomas (GB) are the aggressive primary brain tumors with a survival of only ~1.5 years from initial diagnosis. Resistance to conventional therapies and tumor recurrence in GB has been attributed to the presence of glioma stem cells (GSCs), a subpopulation of cells which exhibit self-renewal and tumorigenesis. Brachyury, an evolutionarily conserved member of T-box family transcription factors, has been implicated in pathobiology of chordomas, lung cancer and hepatocellular carcinoma in adults; it regulates epithelial-mesenchymal transition and chemoresistance in cancer cells. However, the potential role of Brach...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: CELL SIGNALING AND SIGNALING PATHWAYS Source Type: research
Carcinoma cells undergo profound phenotypic changes during progression towards metastasis. One such phenotypic modulation is the epithelial-mesenchymal transition (EMT), an embryonically relevant process that can be reactivated in tumor cells, resulting in the acquisition of metastatic propensity, stem-like cell properties and resistance to a variety of anti-cancer therapies, including chemotherapy, radiation and some small molecule targeted therapies. Targeting of EMT is now emerging as a novel intervention against tumor progression. Brachyury, a transcription factor of the T-box family, is a driver of the phenomenon of E...
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: Tumor Immunology Targets: Oral Presentations - Invited Abstracts Source Type: research
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