In vitro and in vivo efficacy of miramistin against drug-resistant fungi.

CONCLUSION: These findings support further investigation of miramistin and suggest its possible use for treatment of superficial fungal infections. PMID: 31169488 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Respiratory fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis and Candida are the major pulmonary fungal pathogens that are able to result in life-threatening invasive diseases. Growing number of studies have demonstrated that multiple cells and molecules orchestrate host defense against fungal infection in the lung. Upon fungal challenge, innate myeloid cells including macrophages, dendritic cells and recruited neutrophils establish the first line of defense through phagocytosis and secretion of cytokines. Natural killer cells c...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 27 June 2019Source: Microbes and InfectionAuthor(s): Guilhem Janbon, Jessica Quintin, Fanny Lanternier, Christophe d’EnfertAbstractSeminal work by Louis Pasteur revealed the contribution of fungi – yeasts and microsporidia to agroindustry and disease in animals, respectively. More than 150 years later, the impact of fungi on human health and beyond is an ever-increasing issue, although often underestimated. Recent studies estimate that fungal infections, especially those caused by Candida, Cryptococcus and Aspergillus species, kill more than one million people annually. Indeed...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Abstract A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1,3-thiazol-5-yl)-1H-pyrazol-4-yl]-1H-1,2,3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4-ethynyl-1-phenyl-1H-pyrazol-3-yl)-4-methyl-2-aryl-1,3-thiazole (5a-e) with substituted benzyl azide. The starting compounds 5-(4-ethynyl-1-phenyl-1H-pyrazol-3-yl)-4-methyl-2-aryl-1,3-thiazole (5a-e) were synthesized from corresponding 3-(4-methyl-2-aryl-1,3-thiazol-5-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3a-e) by using Ohira-Bestmann reagent. All newly synthesized thiazolyl-pyrazolyl-1,2,3-triazole derivatives were screen...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. An overview of studies on the frequency and determinants of IFI in pediatric oncology patients in nonallogeneic stem cell transplantation settings is lacking. We performed a literature review in Pubmed and Embase, and included 13 prospective and 23 retrospective studies. The IFI frequency (proven/probable based on EORTC criteria) in nonallogeneic stem cell transplantation pediatric cancer patients ranged between 1.0% and 38.0%, with the highest frequencies reported in hematologic malignancies. The most common fungal...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Review Articles Source Type: research
In this study, we tested APX001A and comparators against 1,706 contemporary clinical fungal isolates collected worldwide during 2017 from 68 medical centers in North America (37.3%), Europe (43.4%), Asia-Pacific (12.7%), and Latin America (6.6%). Among the isolates tested, 78.5% were Candida spp., 3.9% were non-Candida yeasts, including 30 Cryptococcus neoformans var. grubii (1.8%), 14.7% were Aspergillus spp., and 2.9% were other moulds. All isolates were tested by CLSI reference broth microdilution.APX001A (MIC50/90, 0.008/0.06 μg/ml) was the most active agent tested against Candida spp. isolates; corresponding anidul...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Authors: Lilienfeld-Toal MV, Wagener J, Einsele H, Cornely OA, Kurzai O Abstract BACKGROUND: The incidence of invasive fungal infection is approximately 6 cases per 100 000 persons per year. It is estimated that only half of such infections are detected during the patient's lifetime, making this one of the more common overlooked causes of death in intensive-care patients. The low detection rate is due in part to the complexity of the diagnostic work-up, in which the clinical, radiological, and microbiological findings must be considered. Fungi with resistance to antimycotic drugs have been found to be on the rise a...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
The epidemiology of invasive fungal infections (IFIs) after liver transplantation (LT) is continuing to evolve in the current era of antifungal prophylactic therapy. This multicenter retrospective cohort study aimed to evaluate the epidemiology, risk factors, and outcomes of IFIs among LT recipients in the current era. We analyzed a total of 482 LT recipients aged 18 years and older who were admitted to 3 tertiary hospitals in Korea between January 2009 and February 2012. Twenty-four episodes of IFIs occurred in 23 patients (4.77%; 23/482). Of these episodes, 20 were proven cases and 4 were probable cases according to EO...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Soghra Khani, Sima Sadat Seyedjavadi, Hadi Zare-Zardini, Hamideh Mahmoodzadeh Hosseini, Mehdi Goudarzi, Shohreh Khatami, Jafar Amani, Abbas Ali Imani Fooladi, Mehdi Razzaghi-AbyanehAbstractThe increasing resistance of pathogenic fungi to conventional antifungal therapies is a major global health concern. Currently, antifungal peptides are receiving increasing attention as suitable candidates for antifungal drug discovery. In the present study, an antifungal peptide was isolated from Satureja khuzistanica by reverse phase-HPLC column and sequenced by ...
Source: Phytochemistry - Category: Chemistry Source Type: research
Publication date: Available online 6 May 2019Source: Journal of Microbiological MethodsAuthor(s): Janet Cheruiyot Kosgey, Lina Jia, Yong Fang, Jianxun Yang, Lei Gao, Jielin Wang, Rose Nyamao, Martin Cheteu, Dandan Tong, Vitalis Wekesa, Natalia Vasilyeva, Fengmin ZhangAbstractFungal burden throughout the world is very high and it keeps escalating due to increasing numbers of immunocompromised individuals. In contrast, the drugs used in management of fungal infections are so few some with high toxicity. Furthermore, highly resistant fungal pathogens are emerging for example Candida auris, Candida glabrata, Candida gullemondi...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Melissa Alves1†, Maria José Gonçalves1†, Mónica Zuzarte2, Jorge M. Alves-Silva1,2, Carlos Cavaleiro1, Maria Teresa Cruz3 and Lígia Salgueiro1* 1CIEPQPF – Department of Chemical Engineering and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal 2Faculty of Medicine, CNC.IBILI, University of Coimbra, Coimbra, Portugal 3Faculty of Pharmacy, CNC.IBILI, University of Coimbra, Coimbra, Portugal Fungal infections remain a burden worldwide, thus underpinning the need for effective new therapeutic approaches. In the present study, the antifungal effect of the es...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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