Is selenoprotein K required for Borrelia burgdorferi infection within the tick vector Ixodes scapularis?

Tick selenoproteins are involved in regulating oxidative and endoplasmic reticulum stress during prolonged tick feeding on mammalian hosts. How selenoproteins are activated upon tick-borne pathogen infection i...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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CONCLUSIONS: This review has concentrated on I scapularis-transmitted diseases affecting the Upper Midwest and has explored the ecology of the I scapularis vector and its role in pathogen transmission. PMID: 32348066 [PubMed - in process]
Source: WMJ - Category: General Medicine Authors: Tags: WMJ Source Type: research
Publication date: Available online 9 January 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Vesta Matulaityte, Algimantas Paulauskas, Maksim Bratchikov, Jana RadzijevskajaAbstractIxodes lividus Koch, 1844 (Ixodida: Ixodidae) ticks are parasites specific to the sand martin (Riparia riparia). The distribution range of I. lividus covers Europe and Asia and they are found wherever sand martins nest. Borrelia burgdorferi sensu stricto, Borrelia garinii and Rickettsia vini have recently been detected in I. lividus ticks in Central Europe. The aim of this study was to investigate the presence of Rickettsia spp. (Rickettsiale...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Borrelia burgdorferi and Anaplasma phagocytophilum are tick-borne infections transmitted by Ixodes scapularis in the eastern USA; both agents cause disease in dogs and people. To characterize changes in seropreva...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
der F Abstract Introduction: Despite advancements in diagnostic capabilities and the availability of effective antimicrobial agents, community-acquired infections of the central nervous system (CNS) are still associated with high mortality rates. Aim: To assess the epidemiological and clinical characteristics of community-acquired CNS infections treated in the West Pannonian region between 2010 and 2016. Method: Clinical data of 176 patients were retrospectively analysed in two age cohorts: 15 to 65 and more than 65 years of age. Results: Neuroinfections were found to be bacterial in 81, viral in 91, parasitic in ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
Publication date: Available online 16 August 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Ilaria Pascucci, Marco Di Domenico, Giulia Capobianco Dondona, Annapia Di Gennaro, Andrea Polci, Andrea Capobianco Dondona, Elisa Mancuso, Cesare Cammà, Giovanni Savini, Jacopo G. Cecere, Fernando Spina, Federica MonacoAbstractThe continuous flow of billions of birds between Africa and Europe creates an “ecological bridge” between physically remote areas. Migratory birds fly south from their breeding grounds during late summer/fall and fly back in spring. These movements regulate the spread of internal and ex...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
This study demonstrates the effect of only simultaneous infection by B. burgdorferi and B. microti on each pathogen, immune response and on disease manifestations with respect to infection by the spirochete and the parasite. In our future studies, we will examine the overall effects of sequential infection by these pathogens on host immune responses and disease outcomes.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 8 June 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Amira Nebbak, Handi Dahmana, Lionel Almeras, Didier Raoult, Nathalie Boulanger, Benoit Jaulhac, Oleg Mediannikov, Philippe ParolaAbstractFifty nymphal Ixodes ricinus ticks collected in Alsace, France, identified by morphological criteria and using MALDI-TOF MS, were tested by PCR to detect tick-associated bacteria and protozoan parasites. Seventy percent (35/50) of ticks contained at least one microorganism; 26% (9/35) contained two or more species. Several human pathogens were identified including Borrelia burgdorferi s.s. (4%), ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Authors: Boulanger N, Boyer P, Talagrand-Reboul E, Hansmann Y Abstract Ticks are a major group of arthropod vectors, characterized by the diversity of pathogens they transmit, by their impact on human and animal health, and by their socioeconomic implication especially in countries of the Southern Hemisphere. In Europe, Ixodes is the most important tick due to its wide distribution in the ecosystems and the variety of transmitted pathogens, in particular Borrelia (responsible for Lyme borreliosis), but also the tick-borne encephalitis virus. Their increased presence in the environment since the beginning of the 20t...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
In this study, the prevalence of antibodies against two Babesia spp. was investigated in a cohort of patients that were seropositive for Borrelia (B.) burgdorferi sensu lato (s.l.). Data were compared to a control group of healthy individuals. Sera were collected from 283 individuals residing in the southernmost region of Sweden, Skåne County. Almost one third of the sera were from patients with a confirmed seropositive reaction against B. burgdorferi s.l. All sera samples were assessed for IgG antibodies against Babesia (Ba.) microti and Ba. divergens by indirect fluorescent antibody (IFA) assays. Seropositive IgG t...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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