Irritant and allergic contact dermatitis - skin lesion characteristics.

IRRITANT AND ALLERGIC CONTACT DERMATITIS - SKIN LESION CHARACTERISTICS. Acta Clin Croat. 2018 Dec;57(4):713-720 Authors: Novak-Bilić G, Vučić M, Japundžić I, Meštrović-Štefekov J, Stanić-Duktaj S, Lugović-Mihić L Abstract - Contact skin lesions may be the consequences of contact with various irritants or allergens, or due to other factors (e.g., UV radiation, microbials), intrinsic factors (e.g., in autoimmune responses), or even their combination. There are many substances related to irritant contact dermatitis (CD), causing irritant or toxic effects, e.g., chemical and physical agents, plants, phototoxic agents, airborne irritants, etc. Impaired barrier function (e.g., aberrancies in epidermal pH buffering capabilities) also participates by promoting bacterial biofilms and creating an environment favoring sensitization. Development of allergic CD skin lesions includes complex immune pathways and inflammatory mediators, influenced by both genetic (predominantly filaggrin mutations) and environmental triggers. In the pathogenesis of allergic CD, antimicrobial peptides play a prominent role; they are produced by various skin cells (e.g., keratinocytes, sebocytes) and move to inflamed lesions during an inflammation process. Also, in allergic CD skin lesions, the skin shows different types of immune responses to individual allergens, although clinical manifestations do not depend on the causative allergen type, e.g., nickel stimulates ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research

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Authors: Ferrucci S, Tavecchio S, Berti E, Angileri L Abstract Atopic dermatitis (AD) is a common chronic multifactorial dermatosis that can occurs through different clinical phenotypes although all undergone identical pathogenetic mechanisms such as the Prurigo Nodularis (PN)-like phenotype. Here, we described eleven patients with PN-like atopic dermatitis treated with dupilumab, a human monoclonal IgG4 antibody that inhibits interleukine-4 (IL-4) and interleukine-13 (IL-13). Efficacy outcomes were performed at baseline, at first and fourth months from starting treatment. We collected different scores such as NRSi...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Wu KK, Borba AJ, Deng PH, Armstrong AW Abstract The association between atopic dermatitis (AD) and conjunctivitis in adults has not been well established. We conducted a cross-sectional study of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) from 2002-2015 in order to evaluate the association between AD and conjunctivitis in U.S. adults. We performed multivariable logistic regression analyses adjusting for sociodemographic factors. An estimated total [95% CI] of 8,581,098 [7,592,037-9,570,160] weighted AD visits and 12,853,199,920 [12.808,2...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
In conclusion, the newly developed topical endocannabinoid membrane transporter inhibitor (WOL067-531) minimized allergic flares and pruritus in a canine model of AD.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
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Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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Source: Clinical Epigenetics - Category: Research Authors: Tags: Research Source Type: research
ConclusionsThere was a significant statistical relationship between the concentration of particulate matter (PM2.5 and PM10) and exacerbation of sleep disturbance and itching. PM2.5 showed a stronger relationship with the exacerbation of symptoms compared to PM10.
Source: Journal of Environmental Health Science and Engineering - Category: Environmental Health Source Type: research
This study evaluated nemolizumab plus topical corticosteroids in patients with AD and severe pruritus and found a significant effect on cutaneous signs of AD (by EASI and IGA), plus a rapid reduction of pruritus.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractThe microbiome is defined as the sum of microbes, their genomes, and interactions in a given ecological niche. Atopic dermatitis is a multifactorial chronic inflammatory skin disease leading to dryness and itchiness of the skin. It is often associated with comorbidities such as allergic rhinoconjunctivitis and asthma. Today, culture-free techniques have been established to define microbes and their genomes that may be both detrimental and beneficial for their host. There are signs that microbes, both on skin and in the gut, may influence the course of atopic dermatitis. Antiseptic treatment has been used for decade...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
ConclusionsFurther studies are needed to better describe the correlation between genotype and phenotype in patients with PAPA syndrome and with PAPA syndrome associated with FMF, considering that the presence of mutations in both genes may amplify clinical presentation and evolution of both diseases.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Condition:   Dermatitis, Atopic Interventions:   Drug: P3-Fast;   Drug: Comm-Fast;   Drug: Vari-Fast;   Drug: Comm-Fed Sponsor:   Pfizer Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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