The prevalence of onychomycosis in the zagreb area - the role of sabouraud agar without cycloheximide in diagnosis and therapy.

THE PREVALENCE OF ONYCHOMYCOSIS IN THE ZAGREB AREA - THE ROLE OF SABOURAUD AGAR WITHOUT CYCLOHEXIMIDE IN DIAGNOSIS AND THERAPY. Acta Clin Croat. 2018 Dec;57(4):726-735 Authors: Mendek S, Lugović-Mihić L, Ferček I, Japundžić I, Šitum M, Abram M Abstract - Mycological analysis is considered the gold standard in the diagnosis of very common fungal diseases of nails. The purpose of the article is to present the prevalence of onychomycosis obtained by using direct microscopic examination (DME) and cultivation on Sabouraud media without cycloheximide. The quantitative retrospective research was conducted on 2706 patients of both sexes (mostly middle-aged to elderly) with various toenail lesions, who had undergone mycological analyses in the Mycological Laboratory of our Department of Dermatovenereology in 2013 and 2014. Analysis of the results obtained revealed that there were 35.4% of positive DME results; of these, there were 39.2% of dermatophytes, 59.1% of yeasts and 1.7% of molds. The percentage of dermatophytes (Trichophyton spp.) was twice as high in men as in women. A considerable percentage (12%) of mixed isolates was also observed. Particularly worrisome was the high percentage (one-third) of suppressed and insufficiently developed dermatophytes (a possible indicator of inappropriate preparation of patients for mycological analysis). Cultivation on culture media without cycloheximide requires frequent inspections because of the fast-growin...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research

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Onychomycosis is a common disorder that is difficult to cure. It has a prevalence ranging from 2-13% globally, across all age groups. Prevalence is lower in children (0.7%), but athletes are 2.5-fold more likely to develop the disease, with toenail infections 7 times more prevalent than infection of the fingernails. This is a concern for athletes as it can interfere with their performance. The risk of developing onychomycosis is increased by the warm environment of many sports activities, the use of occlusive footwear, the warm, moist environment associated with socks and sweating, shared, close quarters among athletes, an...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Purpose: Onychomatricoma is an uncommon but benign neoplasm of the nail matrix that has been rarely reported in literature and often misdiagnosed. Fewer than 100 cases have been reported, and multiple tumors were initially misdiagnosed and treated as primary onychomycosis. It predominantly affects women (2-16:1) with a peak incidence in the fifth decade with only one pediatric case ever been reported. It is most commonly seen in Caucasians and has a predilection for fingers rather than toes. The classic clinical signs of OM include xanthonychia, nail plate hypertrophy, splinter hemorrhages, transverse overcurvature of the ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Tinea unguium, or onychomycosis, is a fungal infection of the nail caused by dermatophytes, yeasts, and nondermatophyte moulds. Effective and efficient treatment is necessary to successfully manage these stubborn infections.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has been reported to be clinically effective for treating onychomycosis. However, there was no report of Nd:YAG laser treatment for the pediatric onychomycosis. Herein, we report a case of Nd:YAG laser treatment in pediatric onychomycosis. An 11-year-old girl presented with palmopalntar keratoderma and dystrophic nails. Microscopic examination of nail scaling before treatment with 20% potassium hydroxide was positive for fungal hyphae. Nails with onychomycosis were treated by 1064 nm Nd:YAG laser and topical epinaconazole.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
CONCLUSION: Continuous terbinafine and pulse itraconazole were similar in efficacy for curing NDM onychomycosis. Age was the most consistent prognostic factor affecting likelihood of cure, with factors that may influence drug reaching the site of infection also decreasing likelihood of mycological cure. PMID: 31415182 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
We describe a real-time PCR assay for 15 different fungi that are associated with onychomycosis. Of 425 clinical samples suspected of onychomycosis analyzed by fungal culture and PCR, 219 samples were positive for both (52% agreement). Of the 206 discordant samples, 95% were resolved in favor of PCR by DNA sequencing. On a larger data set of 2,452 samples, positivity rates for histopathology, PCR, and culture were 85%, 73%, and 54% respectively. Further, 48% of PCR positive and 51% of histopathology positive samples were negative by culture. PCR outperformed culture compared to histopathology...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Abstract Ingrown toenails account for approximately 20% of foot problems in primary care. The great toe is most often affected. Ingrown toenails occur most commonly in young men, and nail care habits and footwear are most often contributory factors. No consensus has been reached for the best treatment approach, but ingrown nails may be nonsurgically or surgically treated. Nonsurgical treatments are typically used for mild to moderate ingrown nails, whereas surgical approaches are used in moderate and severe cases. Simple nonsurgical palliative measures include correcting inappropriate footwear, managing hyperhidro...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Conclusions: Ciclopirox did not show any potential to induce resistance in T. rubrum and appears endowed of a more complete activity than efinaconazole in the management of onychomycosis, as the nail keratin is a substrate for the growth of fungal cells and the availability in large concentration just in the nail bed may not be sufficient to guarantee the complete eradication of pathogens. PMID: 31332076 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Conclusion: Long-pulsed Nd:YAG 1064-nm laser two-stage treatment was effective for onychomycosis, with significantly improved mycological clearance and clinical efficacy. This trial is registered with ChiCTR 1900021669. PMID: 31316570 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 5 July 2019Source: Journal de Mycologie MédicaleAuthor(s): Z. Rafat, S.J. Hashemi, A.-A. Saboor-Yaraghi, B. Pouragha, A. Taheriniya, A. Moosavi, B. Roohi, R. Arjmand, A. Moradi, R. Daie-Ghazvini, S. BasiriAbstractOnychomycosis or fungal nail infection is one of the most common fungal infections. Nearly 50% of all nail disorders are caused by fungi. This systematic review and meta-analysis was conducted to determine the prevalence of onychomycosis across Iran. We searched English and Persian databases for studies reporting the epidemiologic features of onychomycosis in Iranian peopl...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
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