RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.
RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.
Curr Opin Microbiol. 2014 Nov 1;22C:138-143
Authors: Higgins NP
Abstract
Most bacterial chromosomes and plasmids are covalently closed circular molecules that are maintained in a dynamic supercoiled state. Average supercoil density differs significantly between Escherichia coli and Salmonella. Two related questions are: What protein(s) create supercoil domain boundaries in a bacterial chromosome? and How is supercoil density regulated in different bacterial species? RNA polymerase plays pivotal roles in both of these topological phenomena.
PMID: 25460807 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Higgins NP Tags: Curr Opin Microbiol Source Type: research