Click-chemistry approach to synthesis of functionalized isatin-ferrocenes and their biological evaluation against the human pathogen Trichomonas vaginalis

Publication date: 15 September 2019Source: Journal of Organometallic Chemistry, Volume 896Author(s): Amandeep Singh, David Zhang, Christina C. Tam, Luisa W. Cheng, Kirkwood M. Land, Vipan KumarAbstractCopper-promoted azide-alkyne cycloadditions were attempted to synthesize a series of variedly functionalized 1H-1,2,3-triazole-linked isatin-ferrocene, ferrocenylmethoxy-isatin and isatin-ferrocenyl-chalcone conjugates. The synthesized scaffolds were assayed for their inhibitory activity against T. vaginalis as well as several common normal human flora bacteria. The observed inhibitory activities against T. vaginalis and undetectable inhibition of microflora bacteria suggest that these compounds may be specific against trichomonad protozoa and could serve as a new scaffold for synthesis of novel compounds against this important human pathogen.Graphical abstract

Source: Journal of Organometallic Chemistry - June 7, 2019 Category: Chemistry Source Type: research