LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by downregulating lncRNA HOTAIR.

LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by downregulating lncRNA HOTAIR.
Biosci Rep. 2019 Jun 06;:
Authors: Xiao D, Cui X, Wang X
Abstract
It is known that lncRNA PTCSC3 inhibits thyroid cancer and glioma and STAT3 promotes cancer development. We in this study investigated the potential involvement of PTCSC3 in laryngeal squamous cell carcinoma (LSCC) and explored its interactions with STAT3. In the present study we showed that plasma PTCSC3 was downregulated in early stage LSCC patients, and the downregulation of PTCSC3 separated early stage LSCC patients from control group. LncRNA HOTAIR was upregulated in early stage LSCC patients and was significantly and inversely correlated with PTCSC3 in LSCC patients. PTCSC3 overexpression led to the inhibition of HOTAIR, while PTCSC3 expression was not significantly affected by HOTAIR overexpression. PTCSC3 overexpression mediated the inhibited, while HOTAIR overexpression mediated the promoted proliferation of LSCC cells. However, cell invasion and migration were not significantly affected by PTCSC3 overexpression. In addition, HOTAIR overexpression reduced the inhibitory effects of PTCSC3 overexpression on cancer cell proliferation. Moreover, PTCSC3 overexpression mediated the downregulation of STAT3 and STAT3 overexpression mediated the upregulation of HOTAIR. Therefore, PTCSC3 may negatively interact with HOTAIR through STAT3 to inhibit LSCC cell pr...

Source: Bioscience Reports - June 5, 2019 Category: Biomedical Science Authors: Xiao D, Cui X, Wang X Tags: Biosci Rep Source Type: research