Identification of core genes and clinical roles in pregnancy-association breast cancer based on integrated analysis of different microarray profile datasets.

In conclusion, ASB6 could be a potential predictor and therapeutic target in patient with PABC. PMID: 31171715 [PubMed - as supplied by publisher]
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research

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CONCLUSIONS: Breastfeeding represents a protective mechanism only in patients without genetic breast cancer predisposing mutations. Environmental and reproductive factors can impact the risk and the age of onset of breast cancer in patients carrying pathogenic mutations, but the mechanisms of action are not fully understood. PMID: 31424662 [PubMed - in process]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p’-DDT, p,p’-DDT, and p,p’-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. We focused our analyses on o,p’-DDT exposure given our previous report of a positive association between intrauterine o,p’-DDT exposure and daughter’s breast cancer (BC) risk. Here we estimated associations of intrauterine serum DDTs with MBD in 224 daughters of women in the Child Health and Development Studies pregnancy cohort whose mothers did not develop...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
CONCLUSION: ICs occurred unequally in specific provinceand relatively high-educated women in Korea. They were also diagnosed with early-stage breast cancer with a favorablerecurrence risk, and their outcome was better than those of patients with other breast cancers in breast cancer screening. PMID: 31244292 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
The women’s health technology or so-called femtech market has been on the rise for the last couple of years, but it has mainly revolved around fertility and pregnancy. We believe that female health topics reach far beyond such traditional issues and players should concentrate more on menopause, endometriosis, or mental health, just to name a few areas. Thus, we tried to collect companies which are on top of their game in the conventional fertility and/or pregnancy area, but also start-ups and ventures who are looking way beyond that. Here’s our guide to 10 outstanding companies in women’s health. The w...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Business Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones companies company digital digital health digital health technologies femtech health technology Innovation market women women's health Source Type: blogs
Conclusions: Our model is more reliable and stable to assist doctors predict the SLN metastasis in breast cancer patients before operation. Introduction The incidence of breast cancer is the first in female malignant tumors, in which the highest incidence of breast cancer has been reported in Europe and the United States, however, in recent years, the incidence of breast cancer in China has annually increased (1, 2). Based on surgery as an important step in the treatment of breast cancer, in recent years, different individuals have never stopped exploration of a novel and optimum approach. Besides, NSABP-04, ASCOG-...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to eva...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: Our findings suggest that breastfeeding is associated with reduced risk of both HR+ and ER− and PR− breast cancer among Hispanic women, as reported for other populations, and may attenuate the increased risk in women with a first pregnancy at older ages.
Source: Epidemiology - Category: Epidemiology Tags: Cancer Source Type: research
Lilly Rocha was 37 years old in 2008 when she began having strange symptoms. When people asked her questions, she knew the answers but couldn’t articulate them. A tingling sensation on her left breast became painful. She thought she might have breast cancer, but her doctor assured her she was just experiencing stress from her demanding job. Her symptoms continued to get worse, and doctors continued to dismiss her. Three months later, at work, she became seriously ill. Luckily, her boss recognized the symptoms—chest and jaw pain and numbness in her left hand—and drove her to the nearest emergency room, whe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized heart health Source Type: news
Abstract Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have variable estrogen agonist and antagonist activities in different target tissues. Tamoxifen is an anti-estrogen in the breast used for treatment and prevention of breast cancer, with estrogen agonist activity in the uterus. Raloxifene prevents and treats osteoporosis and prevents breast cancer, and can be safely combined with vaginal but not systemic estrogen. The tissue selective estrogen complex combines conjugated equine estrogens (CEE) with the SERM bazedoxifene (BZA). The five Selective Estrogen Menopause and ...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Cancer treatment — and cancer itself — can threaten fertility. This is a tremendously important survivorship issue for many people. As an oncologist, I’m often asked questions about preserving fertility during cancer treatment. If this issue affects you, here is an overview of key options. When should you talk to your cancer team about fertility? Future children may not be foremost on your mind when you are diagnosed with cancer. Soon afterward, though, it’s worth talking to your doctor about fertility issues, if this is important to you now or might one day become important. Your doctor can explain...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Fertility Infertility Source Type: blogs
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