Bilateral facial paralysis as a rare neurological manifestation of primary Sj ögren’s syndrome: case-based review

AbstractPrimary Sj ögren’s syndrome (pSS) is a chronic autoimmune disorder associated with a variety of systemic presentations. Varied neurological dysfunctions of newly diagnosed adult patients with pSS have been observed in recent years. We aimed to describe a rare case of acute bilateral facial paralysis diagnos ed with pSS for the first time and review the previous studies including similar cases. A 69-year-old female, who had experienced ocular and oral dryness for more than 10 years, presented with bilateral facial palsy. Her laboratory test results showed positive anti-Ro (SSA) and anti-Ro-52 antibodie s. Ophthalmic examination and test of saliva secretion verified xerophthalmia and xerostomia, respectively. Other possibilities of Lyme disease, Möbius syndrome, tumor, bilateral temporal bone fracture, Guillain–Barré syndrome, central nervous system lymphoma and HIV infection were ruled out. A diagnosis of pSS associated with bilateral facial paralysis was made. The literature review revealed one article describing a similar patient. Our case was the only one suffering from acute bilateral facial palsy without other nerve involvement. The presence of such patients reveals that pSS is an u nderlying cause of acute bilateral facial paralysis.
Source: Rheumatology International - Category: Rheumatology Source Type: research

Related Links:

Authors: Kallam A, Armitage JO Abstract INTRODUCTION: T cell lymphomas are a heterogeneous group, with varying incidences, geographic patterns, and risk factors. Although until recently approached in a manner similar to B cell lymphomas, the treatment outcomes are poor and this disease is characterized by high relapse rates. The treatment advances in PTCL have been slow compared to B cell lymphomas. The outcomes of patients who progress following stem cell transplantation are worse. AREAS COVERED: This review focuses on the novel targeted agents that are approved and/or are under investigation for patients with...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Barber MRW, Clarke AE Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. AREAS COVERED: This narrative review provides an overview of rec...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
In this study, we reported clinical, immunologic, and genetic evaluation of two Iranian patients from unrelated families, both suffering from recurrent respiratory tract infections, failure to thrive, interstitial lung disease, autoimmune cytopenia, and hypogammaglobulinemia. Pulmonary abscess in one patient and persistent enteropathy in another were also observed. Further investigations revealed causative mutations in the exon (c.2166_2766del) and intron (c.4730-3 T > G) of the LRBA gene. These results may provide further elucidation of the clinical phenotypes and responsible genetic factors of LRBA defi...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses. Aberrant activation of Tfh cells contributes substantially to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Nonetheless, the molecular mechanisms mitigating excessive Tfh cell differentiation are not fully understood. Herein we demonstrate that the adenovirus E4 promoter-binding protein (E4BP4) mediates a feedback loop and acts as a transcriptional brake to inhibit Tfh cell differentiation. Furthermore, we...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Although fluorodeoxyglucose PET/MR imaging is a promising new modality, there is not yet enough data to support its routine use for staging or surveillance of children with lymphoma. PET/MR imaging protocols are still under development, and its availability globally is limited. The cost-benefit of using PET/MR imaging has not yet been established, especially because annual post-treatment surveillance imaging with fluorodeoxyglucose PET is not necessary in most patients with lymphoma. Further research into the use of PET/MR imaging in pediatric oncology patients is needed with continued collaborations among institutions.
Source: PET Clinics - Category: Radiology Authors: Source Type: research
Conclusion: Current treatments, including more intensive chemotherapy regimens, achieve good control of the disease. Novel drugs combined with cellular immunotherapy initially show promising therapeutic effects, and more clinical trials are required to confirm these effects further. PMID: 32476626 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Condition:   Bell Palsy Interventions:   Device: Therapeutic Pulsed Ultrasound;   Device: Sham Ultrasound Sponsor:   Fatih Sultan Mehmet Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   B-cell Non Hodgkin Lymphoma Intervention:   Biological: GC022F Sponsors:   Hebei Yanda Ludaopei Hospital;   Gracell Biotechnology Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 2 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Andrea Cassoni, Carlo Catalano, Danilo Di Giorgio, Ingrid Raponi, Martina Di Brino, Stefano Perotti, Valentino Valentini
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
With America on lockdown the past two months, many people turned to the woods for safe isolation and social distancing. And now as sections of the country reopen and summer approaches, the outdoors...(PRWeb June 02, 2020)Read the full story at https://www.prweb.com/releases/knowing_signs_and_symptoms_of_lyme_disease_is_critical_for_early_detection_and_treatment_says_industry_leading_quidel/prweb17162063.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news
More News: Autoimmune Disease | Bell's Palsy | Brain | Laboratory Medicine | Lyme Disease | Lymphoma | Neurology | Opthalmology | Orthopaedics | Primary CNS Lymphoma | Rheumatology | Study | Xerostomia