Bilateral facial paralysis as a rare neurological manifestation of primary Sj ögren’s syndrome: case-based review

AbstractPrimary Sj ögren’s syndrome (pSS) is a chronic autoimmune disorder associated with a variety of systemic presentations. Varied neurological dysfunctions of newly diagnosed adult patients with pSS have been observed in recent years. We aimed to describe a rare case of acute bilateral facial paralysis diagnos ed with pSS for the first time and review the previous studies including similar cases. A 69-year-old female, who had experienced ocular and oral dryness for more than 10 years, presented with bilateral facial palsy. Her laboratory test results showed positive anti-Ro (SSA) and anti-Ro-52 antibodie s. Ophthalmic examination and test of saliva secretion verified xerophthalmia and xerostomia, respectively. Other possibilities of Lyme disease, Möbius syndrome, tumor, bilateral temporal bone fracture, Guillain–Barré syndrome, central nervous system lymphoma and HIV infection were ruled out. A diagnosis of pSS associated with bilateral facial paralysis was made. The literature review revealed one article describing a similar patient. Our case was the only one suffering from acute bilateral facial palsy without other nerve involvement. The presence of such patients reveals that pSS is an u nderlying cause of acute bilateral facial paralysis.
Source: Rheumatology International - Category: Rheumatology Source Type: research

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CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 18 June 2019Source: Neurochemistry InternationalAuthor(s): Yu Chen, Zheng-Xue Zhang, Liu-Pu Zheng, Li Wang, Yin-Feng Liu, Wei-Yong Yin, Yan-Yan Chen, Xin-Shi Wang, Sheng-Tao Hou, Jiang-Fan Chen, Rong-Yuan ZhengAbstractMultiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine receptor A2A antagonist SCH58261 at different periods of EAE dev...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
AbstractThe sympathetic nervous system (SNS) serves to maintain homeostasis of vital organ systems throughout the body, and its dysfunction plays a major role in human disease. The SNS also links the central nervous system to the immune system during different types of stress via innervation of the lymph nodes, spleen, thymus, and bone marrow. Previous studies have shown that pituitary adenylate cyclase-activating polypeptide (PACAP, gene name adcyap1) exhibits anti-inflammatory properties in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Because PACAP is known to regulate SNS function, we...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 18 June 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Lakshmi Sunkaraa, Syed Mudasir Ahmad, Mohammad HeidariAbstractMarek’s disease virus (MDV), a highly cell-associated oncogenic avian α-herpesvirus, is the causative agent of malignant transformation of T cells in domestic chickens. The latently infected CD4+CD8- T cells carry the virus through the blood stream and establish lymphomas in the skin, visceral organs and peripheral nerves. The feather follicle epithelium (FFE) is the only anatomical site where fully infectious enveloped virions are produced and ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Authors: Vassalini P, Ajassa C, Di Ruscio V, Morace A, Vergari J, Tosato C, Savelloni G, Mastroianni CM Abstract Drug-induced aseptic meningitis (DIAM) represents a diagnostic challenge since clinical and cerebrospinal fluid (CSF) findings may be indistinguishable from a bacterial meningitis. Intravenous immunoglobulin (IVIg) are commonly used in a variety of diseases, including inflammatory and autoimmune disorders. Although usually well-tolerated, various adverse effects have been reported. DIAM is a serious neurological side effect of IVIg therapy: albeit rare (0.067% of all IVIg infusions), the condition repres...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Conditions:   Melanoma;   Hodgkin Lymphoma;   Non Small Cell Lung Cancer Intervention:   Sponsor:   University of Cologne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Doctors often ask their patients to follow specific instructions as part of their prescribed treatment and hope that they do so. However, physicians currently have few ways of tracking a patient’s compliance. They can only base their diagnoses and recommended course of action on what they observe and hear from the patient in the examination room. When patients are asked to share their own accounts of their health condition and treatment progress, their reports can be limited or incomplete – it’s only human nature. Instead, real-world data should supplement t...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
What role could PHH3 immunohistochemistry have in the grading of follicular lymphoma?American Journal of Clinical Pathology
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pathology & Lab Medicine Journal Article Source Type: news
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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