Nicotinic receptor dependent regulation of cough and other airway defensive reflexes

We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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In this study, we aimed to investigate the protective effects and underlying antitussive mechanisms of Suhuang on pulmonary function in ovalbumin (OVA)-induced CVA rats. Administration (i.g.) of Suhuang significantly alleviated pulmonary damage and dysfunction. Suhuang improved ER stress and PKCε translocation via regulation of Ca2+ trafficking. Suhuang also inhibited NLRP3 inflammasome activation, as evidenced by disrupting the assembly of NLRP3 inflammasome and reducing the expression of cleaved caspase-1, and decreased IL-1β secretion. Besides, it’s identified that TXNIP induction and RIP1-RIP3-Drp1 p...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Abstract The allergic airway diseases, including chronic rhinosinusitis (CRS), asthma, allergic bronchopulmonary mycosis (ABPM) and many others, comprise a heterogeneous collection of inflammatory disorders affecting the upper and lower airways and lung parenchyma that represent the most common chronic diseases of humanity. In addition to their shared tissue tropism, the allergic airway diseases are characterized by a distinct pattern of inflammation involving the accumulation of eosinophils, type 2 macrophages, innate lymphoid cells type 2 (ILC2), IgE-secreting B cells, and T helper type 2 (Th2) cells in airway t...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
A large cross-sectional study of UK prescribing data found that the duration of antibiotic prescriptions for common infections in primary care frequently exceeded national guideline recommendations. The most common reason for antibiotic prescribing was for respiratory infections, and more than 80% of prescriptions for acute cough and bronchitis, acute sore throat, acute otitis media and acute exacerbations of COPD were for longer than recommended. Substantial reductions in antibiotic exposure can be achieved by prescribing antibiotics in line with NICE and Public Health England guidance on managing common infections.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Listen to an audio podcast of the January 11, 2018 FDA Drug Safety Communication requiring safety labeling changes for prescription cough and cold medicines containing codeine or hydrocodone to limit the use of these products to adults 18 years and older because the risks of these medicines outweigh their benefits in children younger than 18.
Source: FDA Drug Safety Podcasts - Category: Drugs & Pharmacology Authors: Source Type: podcasts
The diagnosis of pertussis in clinical practice continues to be a challenge worldwide as the symptoms are variable. We aimed to determine the prevalence of pertussis in Chinese children irrespective of cough d...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Cough is a common and chief complaint in primary care. Chronic cough, which is defined as cough lasting for a duration of 4 or more weeks by the American College of Chest Physicians Guidelines (Chang et al., 2017), requires medical attention; it is important to determine the etiology of chronic cough in infants and children. Although chronic cough can be commonly attributed to airway disorders and infectious diseases, it is important to consider less-common diagnoses and use appropriate pediatric guidelines when diagnosing and treating the underlying cause (Bergamini, Kantar, Cutrera,&Italian Pediatric Cough Interest G...
Source: Journal of Pediatric Health Care - Category: Pediatrics Authors: Tags: Case Report Source Type: research
Conclusions: Solid conclusions regarding the respiratory consequences of regular cannabis smoking are difficult to make due to a relative paucity of literature, confounding by concurrent tobacco smoking and reports of conflicting outcomes. Additional well-controlled clinical studies on the pulmonary consequences of habitual cannabis use are needed. PMID: 31298945 [PubMed - as supplied by publisher]
Source: The American Journal of Drug and Alcohol Abuse - Category: Addiction Authors: Tags: Am J Drug Alcohol Abuse Source Type: research
Splenic artery aneurysm in Sjögren's syndrome. Monaldi Arch Chest Dis. 2019 Jul 08;89(2): Authors: Tetikkurt C, Ozseker ZF, KarakaƟ FG Abstract A 40-year-old female presented with cough, exertional dyspnea, abdominal pain with distention, fatigue, dry eyes and dry mouth. Past history revealed asthma. Physical examination was normal except for tachypnea. We found leukocytosis, azygos fissure on chest X-ray along with normal pulmonary function tests and arterial blood gases.  Thorax computed tomography (CT) revealed bronchiectasis and ground glass opacities in both lungs. Abdominal CT demonstr...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Conclusions: In conclusion, RSPH9-associated PCD disease demonstrates wide phenotypic variability. In some cases, mild clinical presentation is difficult to justify diagnostic work-up, highlighting the importance of wider adoption of genetic diagnostics. Larger studies are needed to assess variability of clinical spectrum associated to alterations of PCD genes. PMID: 31285900 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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