Long-Standing AF Tied to Outcomes of Left-Atrial-Appendage Occlusion Long-Standing AF Tied to Outcomes of Left-Atrial-Appendage Occlusion

Long-standing persistent atrial fibrillation (LSPAF) is associated with more residual leak following percutaneous left atrial appendage (LAA) occlusion with the Watchman device, according to one of two new studies of LAA closure.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news

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ConclusionsOur study underscores the importance of an accurate clinical bed-side assessment as the first step in the diagnostic and therapeutic decision-making process for patients presenting with aphasia. The detection of clinical and anamnestic features associated with an epileptic SM could be useful for the diagnostic process and for time-critical treatments.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Clinical NeuroscienceAuthor(s): Chien-Yu Chen, Wei-Chieh Weng, Chia-Lun Wu, Wen-Yi HuangAbstractThe association between gender and stroke outcome in patients with high-grade internal carotid artery (ICA) stenosis remains unclear. We investigate gender differences in clinical characteristics and outcomes in ischemic stroke patients with high-grade ICA stenosis. Three-hundred and seventy-two acute ischemic stroke patients with high-grade ICA stenosis were enrolled and followed up for 5 years. Demographic features, vascular risk factors, co-morbidities, and o...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 14 June 2019Source: The Lancet HaematologyAuthor(s): Matthew S Davids, Danielle M Brander, Haesook T Kim, Svitlana Tyekucheva, Jad Bsat, Alexandra Savell, Jeffrey M Hellman, Josie Bazemore, Karen Francoeur, Alvaro Alencar, Leyla Shune, Mohammad Omaira, Caron A Jacobson, Philippe Armand, Samuel Ng, Jennifer Crombie, Ann S LaCasce, Jon Arnason, Ephraim P Hochberg, Ronald W TakvorianSummaryBackgroundFludarabine, cyclophosphamide, and rituximab (FCR) can improve disease-free survival for younger (age ≤65 years) fit patients with chronic lymphocytic leukaemia with mutated IGHV. However, pat...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Conclusions: Compared with standard management, the SAFETY intervention is potentially a dominant strategy for those with chronic, non-valvular AF. However, there would be substantial value in reducing the uncertainty in these estimates from further research. Trial registration: the Australian New Zealand Clinical Trials Registry (ANZCTRN 12610000221055). PMID: 31190590 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Study Objectives:To evaluate continuous positive airway pressure (CPAP) treatment in patients with moderate to severe sleep-disordered breathing (SDB) after an ischemic stroke.Methods:We identified patients included in the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) who underwent polysomnography after an ischemic stroke. We compared patients without significant SDB (apnea-hypopnea index [AHI]
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
ConclusionsOlder age, history of atrial fibrillation and pneumonia are associated with increased risk of influenza-associated in-hospital and 90-day mortality. Statin use may decrease 90-day mortality.
Source: Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 13 June 2019Source: Canadian Journal of CardiologyAuthor(s): Ian G. Stiell, M. Sean McMurtry, Andrew McRae, Ratika Parkash, Frank Scheuermeyer, Clare L. Atzema, Allan SkanesAbstractThis commentary discusses concerns raised by Canadian emergency physicians regarding Recommendations 2 and 6 from the recent CCS 2018 Update for atrial fibrillation. These recommendations narrow the window for safe cardioversion and suggest four weeks of anticoagulation for all patients undergoing urgent cardioversion regardless of their CHADS-65 status. We discuss the implications of GRADE weak recommendations...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Conditions:   Atrial Fibrillation;   Atrial Fibrillation, Persistent Intervention:   Drug: Ivabradine Sponsor:   Yale University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Bond DA, Alinari L, Maddocks K Abstract Mantle cell lymphoma (MCL) is a heterogeneous and uncommon non-Hodgkin lymphoma that affects predominantly older patients and often is associated with an aggressive clinical course. MCL relies upon B-cell receptor signaling through Bruton tyrosine kinase (BTK); therefore, the development of the BTK inhibitors ibrutinib and acalabrutinib represents a therapeutic breakthrough. In this review, we provide a summary of the efficacy and safety data from the landmark trials of single-agent ibrutinib and acalabrutinib that led to US Food and Drug Administration approval of t...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Conclusion: MCPIP expression was higher in age-related AF than in the other patient groups and it was associated with AF-induced fibrosis.Cardiology
Source: Cardiology - Category: Cardiology Source Type: research
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