Quantitative Ultrasound for Monitoring Bone Status in Institutionalized Adults with Refractory Epilepsy and Intellectual Disability: A 7-year Follow-up Study

Publication date: Available online 7 June 2019Source: SeizureAuthor(s): SLS Cornelissen, JJL Berkvens, IY Tan, K Beerhorst, P Verschuure, S Mergler, HJM Majoie, JPW van den BerghAbstractPurposeLong-term exposure to anti-epileptic drugs has been shown to decrease bone mineral density (BMD). The aim of this 7-year follow-up study was to explore changes in bone status, using quantitative ultrasound (QUS) and Dual-energy X-ray Absorptiometry (DXA) in adults with refractory epilepsy and intellectual disability (ID) residing at a long-term care facility. Both measurements can be challenging to conduct in this population.MethodsIn 2009 and 2016, a total of 126 patients (18-79 years) underwent QUS of the heel and DXA of lumbar spine (LS) and hip (femoral neck (FN) and total hip (TH)). Subgroup analysis was performed for patients with (group A, n = 53) and without (group B, n = 73) bisphosphonate use during follow-up.ResultsOverall, weak to moderate correlations between changes in DXA and QUS parameters were found. For group A, correlations varied from r = .31 to .59, whereas correlations did not exceed r = .40 in group B. Patients in group A showed a larger increase or a smaller decrease in BMD for all DXA regions during follow-up (p 
Source: Seizure - Category: Neurology Source Type: research

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AbstractPhenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microcephaly, epilepsy, motor deficits, intellectual disability, and psychiatric and behavioral disorders. The neuropathology associated with PKU includes defects of myelination, insufficient synthesis of monoamine neurotransmitters, amino acid imbalance across the blood-brain barrier, and involves intermediary...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
CONCLUSIONS: In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. PMID: 31718830 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
We report here the derivation of familial iPSC lines from two controls and three ASD patients carrying NRXN1α+/−, using a non-integrating Sendai viral kit. The genotype and karyotype of the resulting iPSCs were validated by whole genome SNP array. All iPSC lines expressed comparable levels of pluripotency markers and could be differentiated into three germ layers.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This study aimed to provide information on the burden of illness and health-related quality of life (HRQoL) in children with epilepsy who experience prolonged acute convulsive seizures (PACS) in the community setting, and to investigate factors that may predict poor HRQoL in this population.MethodsNoninstitutionalized children (aged 3–16 years) who had experienced at least one PACS within the past year and had currently prescribed PACS rescue medication were enrolled in a cross-sectional study in Germany, Italy, Spain, and the United Kingdom (Practices in Emergency and Rescue medication For Epilepsy managed with Co...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsThese data contribute to identifying an early trend of autism spectrum disorder, useful also for pediatricians.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Publication date: Available online 11 November 2019Source: SeizureAuthor(s): Colin Reilly, Tove Hallböök, Gerd Viggedal, Bertil Rydenhag, Paul Uvebrant, Ingrid OlssonAbstractPurposeThe aim of this study was to compare parent-reported Health Related Quality of Life (HRQoL) and behaviour of young people before (baseline) and two years after paediatric epilepsy surgery (follow-up).MethodsThe parents of 107 children who underwent epilepsy surgery completed surveys focussing on different aspects of child HRQoL and behaviour at baseline and follow-up. Parents of children with multiple disabilities (n = 27...
Source: Seizure - Category: Neurology Source Type: research
Traumatic brain injury (TBI) represents one of the most common causes of death and disability in young people, and posttraumatic epilepsy (PTE) accounts for 10% to 20% of all symptomatic epilepsies. However, PTE is still a relatively underappreciated condi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Dr. Maryam Shanechi. Credit: USC Viterbi ___________________ Is This the Future of Mental Health? (USC Viterbi School of Engineering): “Brain–machine interfaces (BMIs) provide a direct pathway to the brain to translate brain signals into actions … Below, Shanechi (Note: Maryam Shanechi, PhD, assistant professor of electrical and computer engineering) answers some questions about her work and what the future might hold for our understanding and treatment of mental disorders. What potential does this hold for the future not just of mental health, but of understanding our brains as a whole? Neuropsychiatric...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology brain health brain signals brain-machine interfaces depressive disorders emotion regulation engineering future Maryam Shanechi mental health neural Neuroethics neuropsychiatri Source Type: blogs
Abstract PURPOSE OF REVIEW: It is widely accepted that childhood convulsive status epilepticus (CSE) has associated short-term and long-term mortality and morbidity. However, the role of CSE itself on subsequent adverse outcomes is still debated. In addition, whether prolonged seizures cause any long-term hippocampal injury and developmental or memory impairment is uncertain. In this review, we aim to provide an overview of long-term outcomes after childhood CSE, highlighting data from recent literature on this subject. RECENT FINDINGS: Long-term outcome after childhood CSE is favorable in previously normal c...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Opin Pediatr Source Type: research
Purpose of review It is widely accepted that childhood convulsive status epilepticus (CSE) has associated short-term and long-term mortality and morbidity. However, the role of CSE itself on subsequent adverse outcomes is still debated. In addition, whether prolonged seizures cause any long-term hippocampal injury and developmental or memory impairment is uncertain. In this review, we aim to provide an overview of long-term outcomes after childhood CSE, highlighting data from recent literature on this subject. Recent findings Long-term outcome after childhood CSE is favorable in previously normal children, with low in...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: NEUROLOGY: Edited by Robert C. Tasker Source Type: research
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