Personalised medicine in renal cell tumours.

[Personalised medicine in renal cell tumours]. Aktuelle Urol. 2019 Jun 05;: Authors: Junker K, Zeuschner P Abstract The extensive use of abdominal imaging reveals an increasing number of small and asymptomatic kidney tumours, for which primary treatment versus observation strategies need to be discussed. Elaborate surgical techniques and a variety of systemic treatment options are available for patients with localised and advanced tumours. This necessitates a demanding and complex individualised decision-making process. A better understanding of tumour biology including validated biomarkers is therefore essential in order to improve diagnostics, prognostic evaluation and therapeutic strategies.Renal cell tumours are currently subdivided into 16 histological subtypes, each characterised by specific genetic changes. As tumour aggressiveness differs significantly, knowledge of these distinct subtypes is important for adequate treatment choice and follow-up. Molecular markers may facilitate an exact diagnosis and will further differentiate the individual prognosis within each subtype, which is already possible for clear cell renal cell carcinoma (RCC). This will lead to individualised follow-up protocols and a better selection of patients benefitting from observational or adjuvant strategies after surgery.For metastatic tumours, the number of systemic treatment options targeting specific cellular signal or communication pathways has increased tremendously....
Source: Aktuelle Urologie - Category: Urology & Nephrology Authors: Tags: Aktuelle Urol Source Type: research

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Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Li C, Shao T, Bao G, Gao Z, Zhang Y, Ding H, Zhang W, Liu F, Guo C Abstract Most cases of mRCC without an early finding are not candidates for curative therapies, which may be one of the reasons for the poor patient prognosis. Therefore, candidate markers to diagnose the disease and treatment with high efficiency are urgently demanded. Three datasets of mRNA microarray have been assessed to discover DEGs between tissues from metastatic RCC and RCC. 111 DEGs in total were identified according to the expression profile result of genes in the database of GEO. Enrichment analyses for GO and KEGG have been cond...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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Source: Journal of Medical Systems - Category: Information Technology Source Type: research
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Source: Abdominal Imaging - Category: Radiology Source Type: research
Treatment with chimeric antigen receptor-modified T cell (CAR-T) has demonstrated promising therapeutic efficacy in hematologic malignancies. However, the therapeutic efficacy is still very limited for solid tumors. An immunosuppressive microenvironment is one of the main reasons for the limited efficacy. Some chemotherapeutic agents exhibit immune microenvironment modulation. Therefore, combination with chemotherapeutic agents may be one of the promising strategies to enhance the therapeutic efficacy of CAR-T against solid tumors. Sunitinib modulates the antitumor immune response by improving T-cell infiltration and funct...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Basic Study Source Type: research
In conclusion, we described, for the first time, a case series of nivolumab-induced adrenal insufficiency in patients with mRCC. Our findings may be useful for the accurate diagnosis and the prompt treatment of this condition. In addition, there is a possibility that adrenal insufficiency may be associated with a favorable response to nivolumab in patients with mRCC.
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
Authors: Zhang C, Wang N, Su X, Li K, Yu D, Ouyang A Abstract The aim of the present study was to examine the value of FORCE dual-energy CT in grading the clear cell renal cell carcinoma (ccRCC). A total of 35 cases of ccRCC were included. Hematoxylin and eosin staining was performed, and the cases were divided into low- (Fuhrman I-II) and high-grade (Fuhrman III-IV) groups. FORCE dual-energy CT parameters, including virtual network computing CT value (VNCV), iodine overlay value (IOV), mixed energy CT value (MEV), iodine concentration (IC), normalized iodine concentration (NIC), NIC based on aorta (NICA), NIC base...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
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Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
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