LC–MS/MS analysis and network pharmacology of Trigonella foenum-graecum – A plant from Ayurveda against hyperlipidemia and hyperglycemia with combination synergy

ConclusionThe network pharmacology analysis strongly suggested the multimode evidences that TFHE largely works on the insulin signalling pathway and mainly based on its antioxidant potential due to its interaction with carbonic anhydrase. Various compounds were found to be interacting with key proteins that activates EGFR/AKT/mTOR signalling cascade which has therapeutic implication in hyperglycemia and hyperlipidemia. The combination synergy network analysis based on neighbourhood approach can help us in further understanding mechanism of multi-molecular fixed dose combinations.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research