Virome and bacteriome: two sides of the same coin

Publication date: August 2019Source: Current Opinion in Virology, Volume 37Author(s): Jonathan Stern, George Miller, Xin Li, Deepak SaxenaAlthough bacterial dysbiosis has been previously associated with carcinogenesis and HIV infection, the impact of the virome and these disease states has been less well studied. In this review, we will summarize what is known about the interplay between both the bacterial and the viral components of the microbiome on cancer and HIV pathogenesis. Bacterial dysbiosis has been associated with carcinogenesis such as colorectal cancer (CRC), hepatocellular carcinoma (HCC), lung cancer, breast cancer, and gastric cancer. The dysbiotic pathogenesis may be species-based or community-based and can have varying mechanisms of carcinogenesis. The human virome was also associated with certain cancers. Viruses, such as cytomegalovirus (CMV), Human herpesvirus 8 (HHV-8), human papilloma virus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Epstein–Barr virus (EBV), all had associations with cancers. It was also reported that an altered bacteriophage community may lead to carcinogenesis by allowing opportunistic, oncogenic bacteria to proliferate in a gastrointestinal biofilm. This mechanism shows the importance of analyzing the bacteriome and the virome concurrently as their interactions can provide insight into new mechanisms in the pathogenesis of not only cancer, but other diseases as well. The enteric bacteriome was shown to be disti...
Source: Current Opinion in Virology - Category: Virology Source Type: research

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Publication date: Available online 13 July 2019Source: Pathology - Research and PracticeAuthor(s): Lan Luan, Hongying Wang, Beibei Zhao, Fan Wang, Juan Shi, Xiajun XuAbstractThis updated meta-analysis was performed to evaluate the relationship of a common polymorphism (T309 G, rs2279744 T > G) in the murine double minute 2 (MDM2) gene with susceptibility and prognosis of non-small cell lung cancer (NSCLC). The Cochrane Library, PubMed, Embase, CNKI, WanFang and CNKI databases were searched comprehensively for related study. Odds ratios (ORs) with their 95% confidence intervals (95% CI) were c...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 13 July 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Roberto Tozzi, Jvan Casarin, Ahmet Baysal, Ciro Pinelli, Luka Matak, N Ghanbarzadeh, Moiad Alazzam, Riccardo Garruto-Campanile, Hooman Soleymani Majd, Yakup Kilic, Matteo MorottiAbstractObjectivesTo assess the impact of multiple bowel resections on postoperative outcomes in stage IIIC-IV ovarian cancer (OC).MethodsFrom the Oxford OC database we retrieved consecutive patients who underwent bowel resection between January 2009 and November 2017. Patients were divided into two groups: single...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Authors: Park JJ, Won S PMID: 31295992 [PubMed]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
ConclusionsThis study shows that eradication of HCV by DAAs will result in a parallel decrease in IR and improve clinical outcomes in patients with established T2DM.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionThis research is the first to clarify that iridoid glycosides and phenol compounds are the substance basis of the hepatoprotective activity of the EAFVC. Establish rapid and effective method for the determination of main seven compounds, which is vital for the quality control of V. ciliata. These main compounds could be chosen to the analytical marker of V. ciliata. The strong activity of EAFVC and its isolated compounds on relieving the drug-induced liver injury provided the further scientific data for the traditional use and deep development of this Tibetan Medicine. In addition, PASS Online prediction, an effe...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 13 July 2019Source: Seminars in Cancer BiologyAuthor(s): Zoi Piperigkou, Nikos K. KaramanosAbstractThe biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ), which contribute in the progression of several hormone-responsive cancer types via estrogen signaling mechanisms. The coordinated actions of ERs and extracellular matrix (ECM) macromolecules are principal mediators of ECM remodeling in the tumor and the adjacent stroma. In breast cancer, ERs are critical biomarkers as their expression in breast tumor determines the disease-free survival, yet g...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 July 2019Source: Practical Radiation OncologyAuthor(s): Aurelie Garant, Thomas J. Whitaker, Grant M. Spears, David M. Routman, William S. Harmsen, Tyler J. Wilhite, Jonathan B. Ashman, Terence T. Sio, William G. Rule, Michelle A. Neben Wittich, James A. Martenson, Erik J. Tryggestad, Harry H. Yoon, Shanda Blackmon, Kenneth W. Merrell, Michael G. Haddock, Christopher L. HallemeierAbstractPurposeThe purpose of this study was to compare Functional Assessment of Cancer Therapy – Esophagus (FACT-E) questionnaire changes during proton (PRT) or photon (XRT) chemoradiotherapy (CRT) for e...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
We report a patient who had a clinical and morphological presentation consistent with CMML. The genetic work-up showed an ETV6-ABL1 fusion consequent to a 9;12 translocation, and a missense mutation in SMC1A (c.1757G>A, p.Arg586Gln). The SMC1A mutations are recurrent, albeit rare, in myeloid malignancies, without an established clinical significance in CMML. ETV6-ABL1 fusion is a rare but recurrent genetic aberration found in various hematologic malignancies involving both the lymphoid and myeloid lineage, but to the best of our knowledge, CMML is an exceptionally rare presentation of ETV6-ABL1 rearranged neoplasm. ETV6...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
In conclusions, our study found that COL6A3 variants were associated with risk of EC in the Chinese population.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Jason Bugno, Michael J. Poellmann, Karol Sokolowski, Hao-jui Hsu, Dong-Hwan Kim, Seungpyo HongAbstractUltrasmall nanoparticles (NPs,
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
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