Distinguishing logopenic from semantic & nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations.
Distinguishing logopenic from semantic &nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations. Neurocase. 2019 Jun 04;:1-8 Authors: Keator LM, Wright AE, Saxena S, Kim K, Demsky C, Sebastian R, Sheppard SM, Breining B, Hillis AE, Tippett DC Abstract While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral characteristics are less understood. We investigated correlations between language and behavioral scores across three variants of primary progressive aphasia (PPA) and found language performance and behavioral disturbances are correlated in lvPPA, but not other PPA subtypes. Results suggest that unlike other PPA variants, patients diagnosed with lvPPA do not develop negative behaviors until language deficits are severe. This is consistent with the underlying neuropathology of lvPPA, Alzheimer's Disease. Such findings are crucial to clinical prognosis, especially when considering the progressive nature of this disease. PMID: 31164050 [PubMed - as supplied by publisher]
Conditions: Alzheimer Disease, Early Onset; Atypical Alzheimer's Disease; Logopenic Progressive Aphasia Interventions: Device: Anodal tDCS; Device: Sham; Other: Word list learning therapy Sponsor: Johns Hopkins University Not yet recruiting
AbstractThe utility of tau PET imaging in non-Alzheimer ’s disease (AD) tauopathies like behavioural frontotemporal dementia (bvFTD), which is mainly underlain by TDP-43 or tau pathology, remains debated. We aim to test the hypothesis that [18F]-AV-1451 tau PET using later than usual acquisition times, which have previously been shown in AD to allow to get closer to tracer equilibrium between the reference region and high-binding structures, and could be better suited to the lower affinity of this tracer for the straight tau filaments present in non-AD tauopathies, would allow to detect cortical tau pathology in a fr...
DISCUSSION: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD. PMID: 31477517 [PubMed - as supplied by publisher]
DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
ConclusionsAlthough cortical degeneration in AD-related PPA is maximal in the left posterior perisylvian region, it extends more diffusely throughout the left hemisphere language network offering a plausible explanation for why the linguistic profile of lvPPA so often includes additional semantic and grammatic deficits.
Conditions: Alzheimer Disease; Primary Progressive Aphasia; Mild Cognitive Impairment Intervention: Device: repetitive transcranial magnetic stimulation (rTMS) Sponsor: Brigham and Women's Hospital Recruiting