Recap of the first day of the AANP annual meeting

Dr. Maria Martinez-Lage was  kind enough to write the following summary of events at today ’s American Association of Neuropathologists meeting in Atlanta:The opening day of the 95th Annual Meeting of the American Association of Neuropathologists in Atlanta featured a special course dedicated to a topic both old and new: what happens when treatments go awry? Under the title “Unintended Consequences: The Iatrogenic Neuropathology of Systemic Therapies” the faculty discussed neurologic adverse effects of novel immunotherapies,other cancer and non-cancer related treatments, and aspects of immunotherapy and the gut microbiome in Alzheimer ’s Disease. Novel immunotherapies bring novel complicationsThe early morning talks introduced basic concepts and historical notes on cancer immunotherapy. Dr. Dietrich and Dr. Gust, two expert neurologists, explained the intricacies of novel cellular therapies used in hematopoietic malignancies, specifically chimeric antigen receptor T cells (CAR-T) directed against CD19, and their neurotoxic effects. After an excellent introduction, several clinicopathological cases were described to illustrate the characteristics of Immune-effector Cell Associated Neurotoxicity Syndrome (ICANS) and the potential underlying pathophysiological mechanisms, including cytokine release and neurovascular unit injury . While treatment wi...
Source: neuropathology blog - Category: Radiology Tags: meetings Source Type: blogs