Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis

Conclusions: This case shows resolution of recalcitrant Acanthamoeba keratitis with oral miltefosine in an immunocompetent patient. Further clinical evidence would be needed to possibly incorporate this medication in the antiamoebic armamentarium.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research

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Publication date: Available online 18 October 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Teck Boon Tew, Hsiao-Sang Chu, Yu-Chih Hou, Wei-Li Chen, I-Jong Wang, Fung-Rong HuPurposeTo study the surgical outcome of therapeutic penetrating keratoplasty (TPK) for medically uncontrolled microbial keratitis at a tertiary hospital in Taiwan over a 14-year period.MethodsThis is a retrospective case series study. Patients who underwent TPK at National Taiwan University Hospital in 2001–2014 were included. Patients were divided into 3 diagnostic groups: bacterial keratitis, fungal keratitis, and acanthamoe...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
This patient with recurrent unilateral ocular complaints, a lid lesion, and keratitis unresponsive to numerous medications as well as a negative work-up for infectious agents leaves us with numerous diagnostic possibilities. These include: viral shedding from the lid lesion as with molluscum, eyelid deformity with corneal exposure, limbal stem cell deficiency of uncertain etiology, ocular surface dysplasia or neoplasia, superior limbic keratoconjunctivitis, vernal keratoconjunctivitis, herpes group viruses, Acanthamoeba keratitis, eyelid foreign body, medicamentosa, and many others.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cataract Source Type: research
Eye, Published online: 25 September 2019; doi:10.1038/s41433-019-0589-6Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review
Source: Eye - Category: Opthalmology Authors: Source Type: research
To report the clinical and microbiological features of Acanthamoeba keratitis (AK) related to contact lens use in a tertiary hospital in China.
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Conclusions: In an in vitro assay, voriconazole reduced the cysticidal activity of 2 commonly used antiamoebic drugs. Although the in vivo drug interactions could be different, these observations may be useful in cases of nonhealing Acanthamoeba keratitis being treated with combination therapies that include voriconazole.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
CONCLUSION: PHMB 0.02% monotherapy for the initial treatment of AK is as effective as biguanide+diamidine combination therapy. Chlorhexidine monotherapy was too infrequent for comparison. The outcome data are the most detailed available. PMID: 31401556 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
New England Journal of Medicine,Volume 381, Issue 3, Page 274-274, July 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionPKP à chaud within 5.3 months after first symptoms of therapy-resistant AK seems to result in better final BCVA than delayed graft surgery if the disease is resistant to a classical topical triple therapy. In addition, early PKP may have a favorable impact on epithelial healing and graft survival.FundingWe thank the Alexander von Humboldt Foundation for supporting the work of Prof. N. Szentm áry at the Department of Ophthalmology of Saarland University Medical Center in Homburg/Saar, Germany. We thank the University of Saarland for funding the medical writing assistance and the Rapid Service Fe...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Eye, Published online: 10 July 2019; doi:10.1038/s41433-019-0482-3Clinical features and serial changes of Acanthamoeba keratitis: an in vivo confocal microscopy study
Source: Eye - Category: Opthalmology Authors: Source Type: research
Nick Humphreys, of Shropshire, noticed a scratch on his right eye in January 2018. By March, he had gone blind because of Acanthamoeba keratitis, a parasitic infection.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Acanthamoeba Keratitis | Chlorhexidine | Corneal Transplant | Corticosteroid Therapy | Free Living Amoebozoa Infection | Opthalmology | Toxicology