Genomic evolutionary patterns of leiomyosarcoma and liposarcoma.

CONCLUSIONS: From a genomic perspective, LMS metastases contain genetic alterations that are also found in primary tumors. WDLPS and DDLPS, however, appear to divergently evolve from a common precursor harboring 12p amplification, rather than as a transformation to a higher-grade tumor. Further efforts to identify specific drivers of these distinct evolutionary patterns may inform future translational and clinical research in STS.
PMID: 31164371 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - June 3, 2019 Category: Cancer & Oncology Authors: Amin-Mansour A, George S, Sioletic S, Carter SL, Rosenberg M, Taylor-Weiner A, Stewart C, Chevalier A, Seepo S, Tracy A, Getz G, Hornick JL, Nucci MR, Quade B, Demetri GD, Raut CP, Garraway LA, Van Allen EM, Wagner AJ Tags: Clin Cancer Res Source Type: research