Leprosy: A great imitator

In recent years, advances in medical diagnosis and treatment have greatly attracted our attention, whereas some rare diseases, such as leprosy, have not found a place in the medical education curriculum; their existence may even be forgotten. Although the prevalence and incidence rates for leprosy have been significantly reduced as a result of the control strategies of the World Health Organization, new cases still appear. A total of 214,783 new cases were reported from 143 countries during 2016, corresponding to the global new-case detection rate of 2.9 per 100,000 population.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research

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Condition:   Tuberculosis Interventions:   Other: ACF with a seed-and-recruit model;   Other: ACF targeting household and neighborhood contacts;   Other: ACF targeting the older population using mobile screening units;   Other: Passive case finding Sponsors:   National University, Singapore;   KHANA Center for Population Health Research;   National Center for Tuberculosis and Leprosy Control;   Cambodian Anti-Tuberculosis Association Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The need to reform the clinical trials process with the patient in mind is becoming ever more apparent. Given the expense and time it takes to find and retain suitable trial candidates, making a trial scientifically rigorous is no longer enough. It must also be compatible with a patient ’s lifestyle.   Participants in clinical trials are not numbers on a spreadsheet. They are customers, consumers, patients and people with complexities, preferences and nuances. Increasingly they are demanding more choice and more involvement in their treatment journey.  New technology that enables pharma to digitise t...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
The US National Institutes of Health describes drug repurposing as “studying drugs that are already approved to treat one disease or condition to see if they are safe and effective for treating other diseases”.The investment and time required to repurpose a drug is significantly less when compared to new drug discovery and could, therefore, translate into potentially lower prices and faster access to new treatments.Government incentives for rare diseases Historically, orphan drugs and their relatively small target populations have been a particularly risky endeavor for pharmaceutical companies. Considering tha...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Scared parents are demanding answers after letters were sent went home saying two students "might" have the rare disease
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
The disease, also known as Hansen's, is a rare condition caused by slow multiplying bacteria which can destroy sufferers' eyesight and skin. It has been detected in Jurupa Valley near Riverside.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Letter to Editor Source Type: research
Conclusions Media visibility acts as a strategy for legitimising priorities and contextualizing various realities. Therefore, we propose that the health problems identified should enter the public agenda and begin to be recognized as legitimate demands.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Leprosy is a chronic infectious disease caused by Mycobacterium leprae, characterized by a very long incubation period, confounding signs and symptoms and difficulty to establish the onset time. Considering the stigma associated with the diagnosis and the difficulties in detecting asymptomatic leprosy, the incidence and prevalence of this disease are underestimated. In Italy, leprosy is currently included among the rare diseases and can occur as an imported pathology in native individuals or extra-EU immigrants. Currently, given its exceptional appearance in Italy, leprosy is extremely difficult to recog...
Source: Journal of Immigrant and Minority Health - Category: Global & Universal Source Type: research
We reported a case of 56-year-old gentleman presenting with pyrexia of unknown origin, asymmetric sensory motor axonal polyneuropathy and was on chronic exogenous steroid therapy. On evaluation, his skin, muscle, nerve and bone marrow biopsy showed numerous globi of acid-fast Bacilli suggestive of leprous neuromyositis, a rare form of disseminated Hansen's disease. We reported this case in view of its rarity, atypical manifestation of a relatively rare disease and literature review on poor electrophysiological correlation in the diagnosis of leprous neuromyositis as compared to the histopathological examination.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Abstract: Leprosy is a rare disease and unfamiliar to many people. A 55-year-old woman was presented to our hospital complaining of nasal obstruction and anosmia. Nasal endoscopic examination revealed reddish-colored exophytic, nonulcerative masses in both nasal cavities. The authors performed endoscopic sinus surgery which involved endoscopic mass removal and synechiolysis. A biopsy sample stained with acid-fast stain and a rapid silver stain showed numerous filamentous organisms infiltrating macrophages, consistent with lepromatous leprosy. The patient was treated with a triple drug regimen of rifampin and dapsone with c...
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Brief Clinical Studies Source Type: research
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