Therapeutic Effects of Soluble Guanylate Cyclase (sGC) Stimulation on Pulmonary Hemodynamics and Emphysema in Guinea Pigs Chronically Exposed to Cigarette Smoke.

In conclusion, in guinea pigs chronically exposed to CS, sGC stimulation exerts beneficial effects on the lung parenchyma and the pulmonary vasculature, suggesting that sGC stimulators might be a potential alternative for COPD treatment that deserves further evaluation.
PMID: 31166128 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 4, 2019 Category: Cytology Authors: Paul T, Blanco I, Aguilar D, Tura-Ceide O, Bonjoch C, Smolders VF, Peinado VI, Barberà JA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research