Negative affect moderates the effect of social rejection on frontal and anterior cingulate cortex activation in borderline personality disorder.

Negative affect moderates the effect of social rejection on frontal and anterior cingulate cortex activation in borderline personality disorder. Cogn Affect Behav Neurosci. 2019 Jun 04;: Authors: Wrege JS, Ruocco AC, Euler S, Preller KH, Busmann M, Meya L, Schmidt A, Lang UE, Borgwardt S, Walter M Abstract Patients with borderline personality disorder (BPD) have a heightened sensitivity to social exclusion. Experimental manipulations have produced inconsistent findings and suggested that baseline negative affect (NA) might influence the experience of exclusion. We administered a standardized social exclusion protocol (Cyberball paradigm) in BPD (n = 39) and age-matched and sex-matched healthy controls (n = 29) to investigate the association of NA on social exclusion and activation in brain regions previously implicated in this paradigm. Compared with controls, patients with BPD showed higher activation during social exclusion in the anterior cingulate cortex (ACC), the medial prefrontal cortex (mPFC), and in the right precuneus. Prescan NA ratings were associated with higher brain activation in the ACC and mPFC over all conditions, and post hoc t tests revealed that differences between the groups were only significant when controlling for NA. Brain activation during exclusion was correlated with NA separately for each group. Only BPD patients showed a significant association of NA and exclusion related precuneus activation (r = .52 p...
Source: Cognitive, Affective and Behavioral Neuroscience - Category: Neuroscience Authors: Tags: Cogn Affect Behav Neurosci Source Type: research