Expression and Distribution of PIEZO1 in the Mouse Urinary Tract.

Expression and Distribution of PIEZO1 in the Mouse Urinary Tract.
Am J Physiol Renal Physiol. 2019 Jun 05;:
Authors: Dalghi MG, Clayton DR, Ruiz WG, Al-Bataineh MM, Satlin LM, Kleyman TR, Ricke WA, Carattino MD, Apodaca G
Abstract
The proper function of the organs that make up the urinary tract (kidneys, ureters, bladder, and urethra) depends on their ability to sense and respond to mechanical forces including shear stress and wall tension. Yet, we have limited understanding of the mechanosensors that function in these organs and the tissue sites in which these molecules are expressed. Possible candidates include the stretch-activated PIEZO channels (PIEZO1 and PIEZO2), which are implicated in mechanically regulated body functions including touch sensation, proprioception, lung inflation, and blood pressure regulation. Using reporter mice expressing PIEZO1-tdTomato, we find that PIEZO1 is expressed in the kidneys, ureters, bladder, and urethra, as well as organs in close proximity including the prostate, seminal vesicles and ducts, ejaculatory ducts, and the vagina. We further find that PIEZO1 expression is not limited to one cell type: it is observed in the endothelial and parietal cells of the renal corpuscle, the basolateral surfaces of many of the epithelial cells that line the urinary tract, the interstitial cells of the bladder and ureters, and populations of smooth and striated muscle cells. We propose that in the urinary trac...

Source: American Journal of Physiology. Renal Physiology - June 4, 2019 Category: Physiology Authors: Dalghi MG, Clayton DR, Ruiz WG, Al-Bataineh MM, Satlin LM, Kleyman TR, Ricke WA, Carattino MD, Apodaca G Tags: Am J Physiol Renal Physiol Source Type: research