CAD software helps stratify risk in lung cancer patients

By measuring the percentage of pulmonary fibrosis on CT exams in lung cancer...Read more on AuntMinnie.comRelated Reading: Risk models boost efficiency of CT lung cancer screening AI predicts lung cancer survival from CT scan data AI reliably characterizes pulmonary nodules on CT Lung abnormalities at CT linked to in-hospital death CT shows link between statins and lung abnormalities in smokers
Source: Headlines - Category: Radiology Source Type: news

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As extracellular vesicles, exosomes are released from most cells to perform cell–cell communication. Recent studies have shown that exosomes could be released into tumor microenvironment and blood to promote tumor progression through packaging and transmitting various bioactive molecules, such as cholesterol, proteins, lipids, miRNAs, mRNAs, and long non-coding RNAs (lncRNAs) to distant cells. LncRNAs have emerged as a major class of non-coding transcripts. A lot of LncRNAs have been discovered during the past few years of research on genomics. They have been proven to participate in various biological functions and ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Blood tests can tell us a lot about what’s going on in our bodies—from whether we’re eating too much sugar to whether we’re harboring any infectious diseases. Scientists lately have been working on ways to use similar diagnostic tools for cancer, which have the potential to dramatically increase the amount of information doctors use to figure out the best treatments for their patients. Called liquid biopsies, these tests are designed to pick up genetic material shed by cancer tumors into the blood, which lets doctors avoid the invasive procedures needed to extract samples directly from tumors. That ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
Taking aspirin, statins and the drug metformin together reduces the risk for lung cancer by 17%, a study published Thursday by the Journal of Thoracic Oncology found.
Source: Health News - - Category: Consumer Health News Source Type: news
(International Association for the Study of Lung Cancer) Combined use of aspirin, statins, and metformin is associated with decreased lung cancerincidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has killed many people worldwide since December 2019, and Iran has been among the most affected countries. In this retrospective study, we aimed to determine the prognostic factors associated with mortality in COVID-19 patients by analyzing 396 survived and 63 non-survived patients in Shahid Modarres Hospital, Tehran, Iran, from January 30th until April 5th, 2020. As the results, the BMI> 35 (p = 0.0003), lung cancer (p = 0.007), chronic kidney disease (p = 0.002), Immunocompromised condition (p = 0.003), and diabetes (p = 0.018) were more frequently obs...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
In this study, we examined the chemical and biological effects of sterol type elicitors, including squalene, cholesterol and stigmasterol, on polysaccharides (PSs) of Antrodia cinnamomea. Characteristic studies revealed that squalene and stigmasterol effectively increased the glucose contents in PSs. Specifically, squalene not only induced glucose content but also increased fucose and mannose levels in PSs. However, cholesterol did not induce changes in sugar content in PSs. We further identified that high dose squalene significantly promoted 20% yield (w/w) of PSs as well as significantly increased the glucose, galactose ...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Have you ever spent the day in a city with such bad air pollution that when you blew your nose the mucus had a black tinge? Have you ever coughed as you breathed in diesel fumes from a passing bus and thought to yourself, “Well, that’s a year gone from my life”? Could it actually be true — that air pollution leads to an early death? The answer, in fact, is an unqualified yes. Air pollution causes heart disease, lung disease, and early death It has been known for some time that air pollution causes lung cancer, chronic obstructive pulmonary disease, emphysema, asthma, heart disease, and stroke. One r...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Environmental health Healthy Aging Memory Neurological conditions Source Type: blogs
ConclusionErlotinib-related dry skin was associated with a higher CS level in the SC.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Immune checkpoint inhibitors (ICI) have improved survival in numerous types of cancer. However, a great number of unselected patients still do not respond to ICI. Moreover, there is a need to identify biomarkers that could predict the prognosis of immunotherapy-treated patients. The aim of our study is to evaluate the prognostic value of baseline plasmatic cholesterol levels in metastatic cancer patients treated with immunotherapy. We retrospectively enrolled advanced cancer patients consecutively treated with ICI at our center between October 2013 and October 2018 to correlate the blood cholesterol level before treatment ...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
Abstract Small cell lung cancer (SCLC) is a particularly aggressive subset of lung cancer, and identification of new therapeutic options is of significant interest. We recently reported that SCLC cell lines display a specific vulnerability to inhibition of squalene epoxidase (SQLE), an enzyme in the cholesterol biosynthetic pathway that catalyzes the conversion of squalene to 2,3-oxidosqualene. Since it has been reported that SQLE inhibition can result in dermatitis in dogs, we conducted a series of experiments to determine if SQLE inhibitors would be tolerated at exposures predicted to drive maximal efficacy in S...
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Tags: Toxicol Appl Pharmacol Source Type: research
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