NIHR Signal: Iron deficiency in people with chronic kidney disease can be managed with either oral or IV therapy

Expert commentary is provided for a review of 39 RCTs (n=3,852) which found that death and cardiovascular death rates were not different for IV and oral iron. Questions remain about cost-effectiveness and tolerability of both oral and IV therapies.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Authors: Nakano T PMID: 31217397 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Publication date: Available online 21 June 2019Source: Canadian Journal of CardiologyAuthor(s): Mark Canney, Mila Tang, Lee Er, Sean J. Barbour, Ognjenka Djurdjev, Adeera Levin, CanPREDDICT InvestigatorsAbstractBackgroundUsing standard cut-offs derived from healthy adults, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are frequently elevated in patients with reduced glomerular filtration rate (GFR), with unclear implications. We sought to compare GFR-specific cut-offs of each biomarker to standard cut-offs for discrimination of cardiovascular risk in asymptomatic pa...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
DiscussionThis systematic review might help to inform clinicians on the best equation to use in patients with obesity and CKD for staging of CKD and for medication dosing. If no equation is deemed suitable, this review will form a basis for future studies of GFR in obese individuals.Systematic review registrationPROSPEROCRD42018104345
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Conclusion:In this study, we demonstrated that intermediate mesoderm cells could be induced from ADSCs and that they could differentiate well after cocultured with decellularized scaffolds.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
AbstractPurpose of ReviewNon-dialysis-dependent chronic kidney disease (NDD-CKD) patients are at an increased risk of cardiovascular disease (CVD) –related deaths in comparison with the general population. This review summarizes recent guideline recommendations and studies on primary and secondary prevention of traditional cardiovascular (CV) risk factors in those with NDD-CKD.Recent FindingsThe use of antiplatelet agents for primary prevention in CKD is not supported by clinical trial evidence; however, they offer potential benefits when used for secondary prevention of CVD in the absence of an elevated bleeding ris...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
AbstractCongenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease (~  45%) that manifests before 30 years of age. The genetic locus containingCOL4A1 (13q33 –34) has been implicated in vesicoureteral reflux (VUR), but mutations inCOL4A1 have not been reported in CAKUT. We hypothesized thatCOL4A1 mutations cause CAKUT in humans. We performed whole exome sequencing (WES) in 550 families with CAKUT. As negative control cohorts we used WES sequencing data from patients with nephronophthisis (NPHP) with no genetic cause identified (n = 257) an...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Does eating less or more protein affect kidney health? To answer this question, it is important to better understand the pathophysiology of renal function as it pertains to protein intake. Consistent data in both animal models and human subjects suggest that a high-protein diet leads to dilation of the afferent arterioles of the glomeruli. This is usually the result of an amino acid surge in the circulation upon a protein-rich meal. Consequently, increased intraglomerular pressure ensues, which results in elevated glomerular filtration rate (GFR), a phenomenon also known as “glomerular hyperfiltration.” Hence, ...
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Editorial Source Type: research
As I begin my term as Chair of the Council on Renal Nutrition, I can ’t help but reflect on my journey to this point. I have been an registered dietitian nutritionist (RDN) for over 35 years and almost 20 of those years have been in the field of Nephrology. In caring for patients across the full spectrum of this specialty, I have worked with dialysis patients, pre -transplant and post-transplant patients, kidney donors, and CKD patients. I am currently employed in a multidisciplinary Chronic Kidney Disease Clinic.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Message From the Chairperson Source Type: research
Sofosbuvir is the keystone of direct antiviral agents for the chronic hepatitis C (CHC). The safety of sofosbuvir in patients with stage 4 –5 chronic kidney disease (CKD) needs further observation in real world.
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
ConclusionsIn this pilot randomized controlled trial studying patients requiring initiation of HD, we found no difference in absolute SBP decline between those who received mannitol and those who received saline solution. However, there were fewer overall IDH events and a nominally lower risk for dialysis sessions being complicated by IDH in the mannitol group. A larger multicenter randomized controlled trial is warranted.FundingGovernment funding to an author (Dr Mc Causland is supported by National Institute of Diabetes and Digestive and Kidney Diseases grant K23DK102511).Trial RegistrationRegistered at ClinicalTrials.go...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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