What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East?

AbstractIn the West, the incidence of esophageal adenocarcinoma, which is a long-term complication of damage by gastroesophageal reflux, has been rising over recent decades. Two main factors are likely to account for this increase. The first is the rising incidence of central obesity which promotes gastroesophageal reflux. The second is the falling incidence ofH. pylori infection and associated atrophic gastritis which reduces the acidity and peptic activity of gastric juice, the main factors damaging to the esophageal mucosa. The rise in esophageal adenocarcinoma has been mirrored by a fall in gastric cancer consistent withH. pylori atrophic gastritis protecting from the former and predisposing to the latter. The incidence of gastric cancer in Japan is still above the level at which a rise in esophageal adenocarcinoma became apparent in the West. Esophageal adenocarcinoma is likely to rise in Japan also as the incidence of gastric cancer falls but the degree of rise will depend on a variety of other environmental and genetic factors.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research

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Abstract Objective: The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways. Methods: We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at least one night after the procedure. Patients undergoing carotid artery surgery and those who had acute bypass graft thrombosis, cancer, renal failure defined as estimated glomerular filtration rate
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Karekar SR, Marathe PA Abstract Delamanid is a nitro-dihydro-imidazooxazole compound which was developed by a Japanese company, Otsuka Holdings inc. and has shown in-vitro and in-vivo activity against drug resistant tuberculosis. The drug exerts its anti-mycobacterial activity by inhibition of mycolic acid biosynthesis, leading to defective cell wall formation ultimately leading to bacterial death. Following the promising results in Phase 2 trials, Delamanid received approval in European Union in 2014, following which it was also approved in Japan and Korea in the same year. It was approved in India recent...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Ravikirti, Sharma S Abstract Delamanid is a nitro-dihydro-imidazooxazole compound which was developed by a Japanese company, Otsuka Holdings inc. and has shown in-vitro and in-vivo activity against drug resistant tuberculosis. The drug exerts its anti-mycobacterial activity by inhibition of mycolic acid biosynthesis, leading to defective cell wall formation ultimately leading to bacterial death. Following the promising results in Phase 2 trials, Delamanid received approval in European Union in 2014, following which it was also approved in Japan and Korea in the same year. It was approved in India recently ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Twenty five years after the introduction of omeprazole, the first of the PPIs, omeprazole has still remained a valuable drug in the armamentarium of clinicians. PMID: 31324090 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: This study suggested that, KCNQ1 being an established type 2 diabetes gene, genetic variation in this gene may contribute to susceptibility to diabetic nephropathy and the C allele is the risk allele for diabetic nephropathy, which is different from Japanese population where the T allele was the risk allele. PMID: 31324086 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Preventive health care practices among the doctors are low. There an urgent need for them to follow good health care practices which they in turn can advocate to their patients. PMID: 31324085 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: poorer quality maternal diets were observed among the women who were overweight and obese during pregnancy.Resumo Objetivos: investigar a rela ção entre o Índice de Qualidade da Dieta Adaptado para Gestantes (IQDAG) e o excesso de peso materno. Métodos: estudo transversal conduzido entre 754 gestantes adultas em Ribeirão Preto, SP, entre 2011 e 2012. Os critérios propostos por Atalah foram empregados para a classificação do índic e de massa corporal (IMC). Modelos de regressão logística multinomial ajustados foram utilizados para inve...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
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Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Aman Chandra Kaushik, Ajay Kumar, Chun-Yen Yu, Shiao-Wei Kuo, Shih-Shin Liang, Satya P. Singh, Xiangeng Wang, Yan-Jing Wang, Chung-Kun Yen, Xiaofeng Dai, Dong-Qing Wei, Cheng-Tang Pan, Yow-Ling Shiue To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Keum-Soo Song, Satish Balasaheb Nimse, Shrikant Dashrath Warkad, Ae-Chin Oh, Taisun Kim, Young Jun Hong Population-based screening of stage 0 –I lung cancer is crucial for saving lives. The CIC/CYFRA 21-1 ratio allows the detection of stage I lung cancer with 76.0% sensitivity and 87.5% specificity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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