Insulin Resistance and Colorectal Cancer Risk: the Role of Elevated Plasma Resistin Levels

This study was conducted as a case-control study and 170 subjects, including 88 controls and 82 cases with CRC, were enrolled and their plasma levels of glucoe, insulin, and resistin were measured using glucose oxidase or ELISA methods. Moreover, IR was calculated according to HOMA-IR index.ResultsThe cases with CRC had a higher HOMA-IR than the controls (1.8  ± 0.4 versus 1.4 ± 0.3,P 
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Maria Condello, Evelin Pellegrini, Enrico Pierluigi Spugnini, Alfonso Baldi, Bruno Amadio, Bruno Vincenzi, Giovanni Occhionero, Sebastiano Delfine, Franco Mastrodonato, Stefania MeschiniAbstractIn 2018 there were over 1.8 million new cases worldwide of colorectal cancer and relapses after clinical treatments. Many studies ascribe the risk of the appearance of this cancer to the Western life style : a sedentary life, obesity, and low -fiber, high -fat diets can promote the onset of disease. Several studies have shown supplement phyt...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models. Biomed Pharmacother. 2019 Jul 31;118:109281 Authors: Condello M, Pellegrini E, Spugnini EP, Baldi A, Amadio B, Vincenzi B, Occhionero G, Delfine S, Mastrodonato F, Meschini S Abstract In 2018 there were over 1.8 million new cases worldwide of colorectal cancer and relapses after clinical treatments. Many studies ascribe the risk of the appearance of this cancer to the Western life style : a sedentary life, obesity, and low -fiber, high -fat diets can promote the onset of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Yikan Cheng1†, Yan Ma1†, Jian Zheng1†, Hua Deng2†, Xueqin Wang3,4, Yewei Li3,4, Xiaolin Pang1, Haiyang Chen1, Fang He1, Lei Wang5*, Jianping Wang5* and Xiangbo Wan1* 1Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Radiation Oncology, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 2Department of Radiation Oncology, Banner-University Medical Center Phoenix, Phoenix, AZ, United States 3Department of Statistical Science, Southern China Center for Statistical Science, School of Mathe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Adopting these strategies can facilitate laparoscopic mesorectal excision in the obese patient and may reduce conversion to open.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Technical Notes Source Type: research
ConclusionsObesity is positively associated with CC but not RC, and abdominal obesity exerts an independent effect. Reproductive factors had at best a weak effect on CC and RC.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 6 June 2018Source: European Journal of Surgical OncologyAuthor(s): Youri Q.M. Poelemeijer, Niki Lijftogt, Robin Detering, Marta Fiocco, Rob A.E.M. Tollenaar, Michel W.J.M. WoutersAbstractBackgroundObesity is an increasing problem worldwide that can influence perioperative and postoperative outcomes. However, the relationship between obesity and treatment-related perioperative and short-term postoperative morbidity after colorectal resections is still subject to debate.StudyPatients were selected from the DCRA, a population-based audit including 83 hospitals performing colorectal cancer (C...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Abstract Patients with psoriasis have an increased risk of cancer, which may be due to impaired immune surveillance, immune modulatory treatments, chronic inflammation and/or co-risk factors such as obesity. The increase in treatment-independent solid cancers, including urinary/bladder cancers, oropharynx/larynx, liver/gallbladder and colon/rectal cancers, seem to be linked to alcohol and smoking. Lung cancer and nonmelanoma skin cancer are also increased in patients with psoriasis. The risk of nonmelanoma skin cancer increases with age and severity of psoriasis. It is also higher in men, particularly for squamous...
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
Publication date: Available online 6 June 2018Source: European Journal of Surgical OncologyAuthor(s): Youri Q.M. Poelemeijer, Niki Lijftogt, Robin Detering, Marta Fiocco, Rob A.E.M. Tollenaar, Michel W.J.M. WoutersAbstractBackgroundObesity is an increasing problem worldwide that can influence perioperative and postoperative outcomes. However, the relationship between obesity and treatment-related perioperative and short-term postoperative morbidity after colorectal resections is still subject to debate.StudyPatients were selected from the DCRA, a population-based audit including 83 hospitals performing colorectal cancer (C...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
CONCLUSIONS: A robotic approach during the proctectomy and IPAA offers significant advantages to a laparoscopic approach, expanding our armamentarium of minimally invasive surgical techniques to IPAA.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Technical Note Source Type: research
More News: Cancer | Cancer & Oncology | Colon Cancer | Colorectal Cancer | Eating Disorders & Weight Management | Gastroenterology | Insulin | Obesity | Rectal Cancers | Study