Changing hospitalization trends for systemic lupus erythematosus and rheumatoid arthritis in England.

Changing hospitalization trends for systemic lupus erythematosus and rheumatoid arthritis in England. Lupus. 2019 Jun 04;:961203319853357 Authors: Hannah J, Galloway J, Kaul A Abstract OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic, multisystemic, immune-mediated disorder associated with a substantial hospitalization risk. As a comparatively rare disease, there is a sparsity of research examining the burden of hospital admission in the contemporary era. We aim to describe national trends in hospitalization rates in England between 1998 and 2015 for SLE, using rheumatoid arthritis (RA) and general population rates as comparison cohorts for benchmarking. METHODS: Hospital admission rates, emergency and day-case admission rates, length of stay and bed days used were calculated using finished consultant episodes from Hospital Episode Statistics data. Cochran-Armitage tests and linear regression quantified the significance and magnitude of change over time. RESULTS: SLE admissions increased from 8.97 to 9.04 per 100,000 ( p 
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research

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Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Christopher J.M. Piper, Elizabeth C. Rosser, Kristine Oleinika, Kiran Nistala, Thomas Krausgruber, André F. Rendeiro, Aggelos Banos, Ignat Drozdov, Matteo Villa, Scott Thomson, Georgina Xanthou, Christoph Bock, Brigitta Stockinger, Claudia MauriSummaryRegulatory B cells (Bregs) play a critical role in the control of autoimmunity and inflammation. IL-10 production is the hallmark for the identification of Bregs. However, the molecular determinants that regulate the transcription of IL-10 and control the Breg developmental program rem...
Source: Cell Reports - Category: Cytology Source Type: research
Bhanu Mishra, Sunil Prakash, Subhash Chandra, Sanjeev Gera, Ashwini Goel, Amit K Yadav, Ganesh Dhanuka, Satendra YadavIndian Journal of Nephrology 2019 29(6):431-432
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSIONCollectively, it is possible that combination therapy can be applied as a beneficial strategy to control RA.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research
Elvira Sondo1, Roberta Bertelli2, Emanuela Pesce1, Gian Marco Ghiggeri2 and Nicoletta Pedemonte1* 1UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy 2UOC Nefrologia, IRCCS Istituto Giannina Gaslini, Genova, Italy Neutrophils migrate to sites of infection where they phagocytose, degranulate, and/or, in the presence of appropriate stimuli, release decondensed chromatin strands (called neutrophil extracellular traps, NETs) for trapping and possibly killing microorganisms. NET formation is characterized by marked morphological cell changes, in particular within the nucleus. Lytic NET formation can ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study we wanted to examine the expression of ABCs in patients with aplastic anemia. We isolated peripheral blood mononuclear cells (PBMCs) from patients with aplastic anemia (n=10) and eight healthy, age- matched controls. Written informed consent was obtained from all study subjects. Cells were stained with the surface markers CD11c, CD19 and CD21, and subsequently analyzed using flow cytometry. An anti-Tbet antibody was also used after cell permeabilization. The CD11c-high, CD19 positive, CD21 negative, T-bet positive population represent the ABCs.Results: Patients with aplastic anemia at presentation showed incr...
Source: Blood - Category: Hematology Authors: Tags: 508. Bone Marrow Failure Source Type: research
Authors: Silverman ED Abstract The 72nd Annual Meeting of The Canadian Rheumatology Association (CRA) was held at The Westin Ottawa, Ottawa, Ontario, Canada, February 8-11, 2017. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2017 award winners: Dr. Vinod Chandran, Young Investigator; Dr. Jacques P. Brown, Distinguished Investigator; Dr. David Robinson, Teacher-Educator; Dr. Michel Zummer, Distinguished Rheumatologist; Ms. Rebecca Gole, Best Abstract on SLE Research by a Trainee - Ian Watson Award; Ms. Bailey Russell...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
The classification of a population by a specific trait is a major task in medicine, for example when in a diagnostic setting groups of patients with specific diseases are identified, but also when in predictive medicine a group of patients is classified into specific disease severity classes that might profit from different treatments. When the sizes of those subgroups become small, for example in rare diseases, imbalances between the classes are more the rule than the exception and make statistical classification problematic when the error rate of the minority class is high. Many observations are classified as belonging t...
Source: Biometrical Journal - Category: Biotechnology Authors: Tags: Case Study Source Type: research
Pinkeye is another name for conjunctivitis and is a condition that causes inflammation and redness of the membranes inside the eyes. It causes the whites of your eyes to appear reddish or pink. The disease can be caused by a bacterial or viral infection in addition to an allergic reaction. Pinkeye caused by infection is highly contagious. Many children will develop pink eye at a daycare and spread it to others. For this reason, early diagnosis and treatment is extremely important. Pinkeye can affect one or both eyes. Many times it will start in one eye and then spread to the other. The most common symptoms of pink eye are ...
Source: Nursing Comments - Category: Nursing Authors: Tags: Advice/Education Caregiving General Public Nursing/Nursing Students Patients/Specific Diseases allergy bacterial burning conjunctivitis eye discharge eye disease eye drops gritty eyes infection itching matted eyes in morning Source Type: blogs
Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune system and represent 2 sides of the same coin. Multiple single-gene defects have been identified, resulting in rare diseases with features of both autoimmunity and immunodeficiency. On the other hand, more common autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, show a polygenic inheritance pattern. Not surprisingly, the genes implicated in single-gene disorders have also been shown to be linked to polygenic disorders.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Reviews and feature article Source Type: research
Kristin Agar, a 63-year-old social worker, was diagnosed with lupus in 2008, a rare disease in which the body’s own immune system can cause serious damage to the kidneys, brain, skin, and joints. Unfortunately, despite having insurance coverage, Kristin has found that the drug she needs to treat her lupus is unaffordable. All around the United States, Kristin joins other patients with chronic conditions like HIV, Hepatitis C, Multiple Sclerosis, Rheumatoid Arthritis, and Leukemia, who are having trouble paying for their medications. In June, Robert Restuccia and I wrote a Health Affairs Blog post showi...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Costs and Spending Drugs and Medical Technology Equity and Disparities Following the ACA Insurance and Coverage Long-term Services and Supports Payment Policy Population Health Public Health Americans With Disabilities Act chronic dise Source Type: blogs
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