Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis

Nature Reviews Rheumatology, Published online: 05 June 2019; doi:10.1038/s41584-019-0249-zSingle-cell analysis identifies key pathways and prognostic markers in lupus nephritis
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research

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Genital lesions associated with lupus erythematosus (LE) are rarely reported in the literature despite an estimated prevalence of 5% in females with systemic lupus erythematosus (SLE). Investigation of the manifestations of lupus in the genitals can improve the care of lupus patients and further our understanding of this heterogeneous disease. A 38-year-old female with systemic lupus erythematosus (SLE) presented with three weeks of painful oral and vaginal erosions. Her SLE had been well controlled on hydroxychloroquine for five years, until four months prior, when she had worsening joint pain and nephritis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
The optimal duration of maintenance immunosuppressive therapy for patients with lupus nephritis who have achieved clinical remission has not been established. Furthermore, clinical and histologic remissions are often discordant. We postulated that continuing therapy for patients with persistent histologic activity on kidney biopsies done during maintenance and discontinuing therapy only for patients without histologic activity would minimize subsequent lupus nephritis flares. To test this, a cohort of 75 prospectively-followed patients with proliferative lupus nephritis was managed using kidney biopsies performed during maintenance therapy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
ConclusionSerotonin syndrome should be considered in patients on multiple serotonergic agents on the background of end ‐stage renal disease. Prompt recognition and distinction from lupus activity can significantly impact management decisions.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: APLAR GRAND ROUND CASE Source Type: research
CONCLUSIONS: There was no association between the PAI‑1 4G/5G polymorphism and SLE/LN and RA development and significantly higher levels of circulating PAI‑1 were observed in patients with SLE but not in those with RA. PMID: 31428858 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
A recent gene expression analysis found an enriched downstream interferon signature, with predominantly IFNB1 signatures in systemic lupus erythematosus (SLE) patients. The study also found lower expression of all downstream interferon signatures in the kidneys of lupus nephritis patients...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions SLE (Lupus) interferon systemic lupus erythematosus (SLE) Source Type: research
Chinese herbal medicines used in combination have long-term been shown to be mild remedies with “integrated effects”. However, our study provides the first demonstration that M1, an active metabolite of ginsenoside, exerted its dramatic therapeutic effects on accelerated and severe lupus nephritis (ASLN) mice, featuring acute renal function impairment, heavy proteinuria, high serum levels of anti-dsDNA, and high-grade, diffuse proliferative renal lesions. In the present study, NZB/WF1 mice were given injections of lipopolysaccharide to induce the ASLN model. M1 (30 mg/kg) was then administered to the mice by ga...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Lee JM, Kronbichler A, Park SJ, Kim SH, Han KH, Kang HG, Ha IS, Cheong HI, Kim KH, Kim G, Kim DS, Chae HW, Lee CH, Lee KH, Shin JI Abstract Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
ConclusionsIn summary, plasma galectin ‐3 level was not significantly different between SLE patients and controls (P = .982). Further studies are needed to elucidate the role of galectin‐3 in SLE.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionMost nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients.
Source: Microvascular Research - Category: Biochemistry Source Type: research
AbstractA 34-year-old female patient presented to our hospital with lower extremity edema and proteinuria during pregnancy. Renal biopsy was performed and the patient was diagnosed with nephrotic syndrome due to lupus-like membranous nephropathy. This diagnosis was reached upon as laboratory findings upon admission, wherein both anti-nuclear and anti-double-stranded DNA antibodies revealed negative, did not fulfill the criteria for systemic lupus erythematosus (SLE) proposed by the American College of Rheumatology (ACR) and the patient did not reveal any typical physical manifestations of SLE. Methylprednisolone pulse ther...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
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