Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases

AbstractInosine pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine and methisoprinol, has been proven to positively impact the host ’s immune system, by enhancing T-cell lymphocyte proliferation and activity of natural killer cells, increasing levels of pro-inflammatory cytokines, and thereby restoring deficient responses in immunosuppressed patients. At the same time, it has been shown that it can affect viral RNA levels and hence inhibit growth of several viruses. Due to its immunomodulatory and antiviral properties, and its safety profile, it has been widely used since 1971 against viral infections and diseases, among which subacute sclerosis panencephalitis, herpes simplex virus, human papilloma virus, human immunode ficiency virus, influenza and acute respiratory infections, cytomegalovirus and Epstein–Barr virus infections. Following an analysis of almost five decades of scientific literature since its original approval, we here summarize in vivo and in vitro studies manifesting the means in which IP impacts the host’s immune system. We also provide a synopsis of therapeutic trials in the majority of which IP was found to have a beneficial effect. Lastly, positive results from limited studies, suggesting the putative future use of IP in new therapeutic indications are briefly described. In order to s upport use of IP against viral infections apart from those already approved, and to establish its use in clinical practice, furthe...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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Conclusion: This colloidal gold assay may be one of the viable tools for the rapid screening for influenza viruses in an outpatient clinical practice. PMID: 31304835 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Publication date: 16 July 2019Source: Cell Reports, Volume 28, Issue 3Author(s): Dan Xiong, Li Song, Shizhong Geng, Yang Jiao, Xiaohui Zhou, Hongqin Song, Xilong Kang, Yi Zhou, Xiulong Xu, Jun Sun, Zhiming Pan, Xinan JiaoSummaryToll-like receptors (TLRs) activate innate immunity via interactions between their Toll/interleukin-1 (IL-1) receptor (TIR) domain and downstream adaptor proteins. Here we report that Salmonella Enteritidis produces a secreted protein (TcpS) that contains both a TIR domain and a coiled-coil domain. TcpS blocks MyD88- and TRIF-mediated TLR signaling, inhibits inflammatory responses, and promotes bact...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: Available online 16 July 2019Source: Antiviral ResearchAuthor(s): Koen Sedeyn, Xavier SaelensAbstractThe antigenic diversity of human influenza viruses represents a challenge to the development of vaccines with durable immune protection. In addition, small molecule anti-influenza viral drugs can bring clinical relief to influenza patients but the emergence of drug resistant viruses can rapidly limit the effectiveness of such drugs. In the past decade, a number of human monoclonal antibodies have been described that can bind to and neutralize a broad range of influenza A and B viruses. Most of these monocl...
Source: Antiviral Therapy - Category: Virology Source Type: research
Inovio Pharmaceuticals Inc. said it plans to narrow its drug development focus in a move that will result in the elimination of 80 positions, or about 28 percent of the Montgomery County biotechnology company's total workforce. Going forward, Inovio (NASDAQ: INO) said it has "sharpened its corporate strategy" to concentrate on the commercial development of its late-stage drugs candidates targeting the human papillomavirus (HPV) and reallocate capital to develop fast-to-market product candidates.…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Authors: Xiaoqun D, Xiaoli L, Jun L, Yang X Abstract The aim of the present study was to investigate the correlation between human papillomavirus (HPV) type 6/11 and 16/18 infections and glandular thickening mammary gland hyperplasia in order to explore methods for preventing glandular thickening mammary gland hyperplasia. A total of 240 patients with glandular thickening mammary gland hyperplasia who were treated by surgery in our hospital from January 2012 to June 2017 were enrolled in the present study. The hyperplastic breast tissue and adjacent normal breast tissue were taken to test HPV type 6/11 and 16/18 in...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
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Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yoshihiro Minagawa, Hiroshi Ueno, Kazuhito V. Tabata, Hiroyuki Noji A compact and simple smartphone-based mobile imaging platform realized swift single influenza virus counting of clinical samples. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Inovio Pharmaceuticals Inc. said it plans to narrow its drug development focus in a move that will result in the elimination of 80 positions, or about 28 percent of the Montgomery County biotechnology company's total workforce. Going forward, Inovio (NASDAQ: INO) said it has "sharpened its corporate strategy" to concentrate on the commercial development of its late-stage drugs candidates targeting the human papillomavirus (HPV) and reallocate capital to develop fast-to-market product candidates.…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
María Maximina B. Moreno-Altamirano1*, Simon E. Kolstoe2 and Francisco Javier Sánchez-García1* 1Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2School of Health Sciences, University of Portsmouth, Portsmouth, United Kingdom Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in w...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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