Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation

Vascular maturity and functionality are closely associated with tumor progression and chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast...

Source: Journal of Experimental and Clinical Cancer Research - June 4, 2019 Category: Cancer & Oncology Authors: Ji-Chang Wang, Guang-Yue Li, Bo Wang, Su-Xia Han, Xin Sun, Yi-Na Jiang, Yan-Wei Shen, Can Zhou, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Mao-De Wang and Pei-Jun Liu Tags: Research Source Type: research