Influence of Epidural Steroid Injection on Adrenal Function.

Influence of Epidural Steroid Injection on Adrenal Function. Clin Orthop Surg. 2019 Jun;11(2):183-186 Authors: Shin WS, Ahn DK, Kim MJ, Cho KJ, Go YR Abstract Background: Spinal diseases are self-limited or non-progressive in many cases. Epidural steroid injection (ESI) is a common nonsurgical treatment option for spinal pain. Despite concerns about complications of repeated steroid injection, few studies reported on the adrenal function of spine disease patients undergoing surgery after ESI. We investigated the influence of preoperative multiple ESIs on adrenal function in spine surgery patients. Methods: This was a retrospective study with prospective data collection. Those who underwent elective spinal operations and had a history of multiple ESIs from January to June 2017 were selected as a study group. Those who underwent knee arthroplasty and did not have a history of ESI and any kind of steroid injection in other areas during 6 months before surgery were selected as a control group. Demographic data were compared to assess homogeneity between groups. We assessed the preoperative serum cortisol level (SCL) to compare the basal adrenal function between groups. Also, we assessed the elevation of SCL postoperatively to evaluate the adrenal response to the surgical stress in each group. For subgroup analysis, we divided all patients into normal (7-28 µg/dL) and subnormal groups according to SCL and analyzed risk factors of adrenal suppression ...
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

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BY JESSICA DAMASSA Bum knees, aching backs, and neck pain are literally a pain-in-the-neck for millions of people – making chronic pain one of the largest areas of healthcare spending. Is it time to disrupt the traditional delivery of physical therapy? Physera CEO, Dan Rubenstein, thinks so, and talks to us about how his healthcare startup is revolutionizing the way physical therapy is being delivered by taking it virtual and driving down the cost. With more than $10M in funding (their $6M Series A was led by BlueCross BlueShield’s Venture Fund) and a major contract with a nationwide health plan provider in ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Tech Jessica DaMassa WTF Health BlueCross BlueShield Venture Chronic Back Pain chronic disease chronic pain Dan Rubenstein HLTH HLTH 2019 Physera Source Type: blogs
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Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
The autonomic nervous system interacts with the pain system. Knowledge on the effects of high velocity low amplitude spinal manipulations (SM) on autonomic activity and experimentally induced pain is limited. ...
Source: Chiropractic and Osteopathy - Category: Complementary Medicine Authors: Tags: Research Source Type: research
Chronic low back pain (cLBP) is a major health problem and the most common pain condition among those aged 60  years or older in the US. Despite the development of pharmacological and nonpharmacological interve...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
To determine the efficacy of OLIF in the treatment of reoccurring discogenic low back pain (LBP) after discoblock
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research
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Source: Applied Research in Quality of Life - Category: International Medicine & Public Health Source Type: research
ConclusionOur results suggest that a single SM of the thoracic spine has no specific effect on cardiovascular autonomic activity. Also, we found no relationship between cardiovascular autonomic activity and pressure pain threshold after the SM. Further experimental research should consider the use of several markers of autonomic activity and a more comprehensive pain assessment.Trial registrationN °NCT03273868. Registered September 6, 2017.
Source: Chiropractic and Manual Therapies - Category: Complementary Medicine Source Type: research
Conclusion: The results will hopefully lead to a better consideration of stressful factors in the work environment, sleep, and musculoskeletal pain in middle managers.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
Publication date: Available online 19 January 2020Source: NeuroscienceAuthor(s): Xing-Lian Duan, Zhen Guo, Yong-Tao He, Yin-Xia Li, Yan-Ni Liu, Hu-Hu Bai, Hu-Ling Li, Xiao-Dong Hu, Zhan-Wei SuoAbstractSoluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) have been implicated in the trafficking of postsynaptic glutamate receptors, including N-methyl-D-aspartate (NMDA)-subtype glutamate receptors (NMDARs) that are critical for nociceptive plasticity and behavioral sensitization. However, the components of SNAREs complex involved in spinal nociceptive processing remain largely unknown. Here we found ...
Source: Neuroscience - Category: Neuroscience Source Type: research
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