New natural coumarins from Trichocline macrocephala (Asteraceae)

This study reports the isolation and elucidation of two undescribed compounds, named 7-methoxy-glaupalol and 8-hydroxy-isogerberacoumarin, along with glaupalol, 5-methoxycoumarin, 5,6-dimethoxycoumarin and 7-methoxycoumarin. Their structures were determined by application of 1D and 2D NMR techniques and HRESIMS analysis. The 5-methylcoumarin glaupalol exhibited antichemotactic activity on leukocytes migration at concentrations from 0.01 to 5 μg/mL.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research