Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Mei Zhao, Li Yang, Wen-Hua Dong, Wei Li, Hui-Qin Chen, Hao Wang, Cai-Hong Cai, Cui-Juan Gai, Wen-Li Mei, Hao-Fu DaiAbstractIn our ongoing effort to study the metabolites from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) produced in Laos, three new 2-(2-phenylethyl)chromone derivatives (1−3) were isolated. Their structures were elucidated by comprehensive spectroscopic analyses, predominantly by 1D and 2D NMR spectroscopic methods, and by comparison with the reported data. Compound 2 exhibited tyrosinase inhibitory activity with IC50 value of 172.6 ± 1.7 μM (kojic acid as the positive control, 46.1 ± 1.3 μM) and its inhibition mode was clarified by molecular modelling study. None of the isolates showed significant cytotoxicity towards tested cancer cell lines.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research