Acetate Metabolism in Physiology, Cancer, and Beyond.

Acetate Metabolism in Physiology, Cancer, and Beyond.
Trends Cell Biol. 2019 May 31;:
Authors: Bose S, Ramesh V, Locasale JW
Abstract
Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.
PMID: 31160120 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - May 30, 2019 Category: Cytology Authors: Bose S, Ramesh V, Locasale JW Tags: Trends Cell Biol Source Type: research