Beta Blockers Might Fight A-Fib Too

A-fib is a common heart rhythm disorder sometimes triggered by stress and negative emotions. Beta blockers are drugs that block the effects of adrenaline and related substances.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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This study explored the possible protective activity of Skullcapflavone I (SF I), a flavonoid isolated from the root of Scutellaria baicalensis Georgi, on hypoxia-stimulated cardiomyocytes cell injury in vitro. Viability and apoptosis of H9c2 cells and primary cardiomyocytes were tested using cell counting kit-8 (CCK-8) assay and Guava Nexin Reagent, respectively. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to measure the long non-coding RNA regulator of reprogramming (lincRNA-ROR) expression. si-ROR was transfected to knockdown lincRNA-ROR. Western blotting was conducted to assess the p...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Authors: Theoharides TC, Kavalioti M Abstract Learning and motivation are critical in the development of children, and to their acquisition of knowledge and skills. A case in point is autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impaired social interactions and communication, as well as by stereotypic movements. Maternal stress has been strongly associated with increased risk of developing ASD. Children experience multiple stressors such as separation anxiety, fear of the unknown, physical and/or emotional trauma, bullying, as well as environmental exposures. Stress is well known ...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
CONCLUSION: Ferulic acids are known to contrarily down-manage an assortment of extracellular and intracellular atomic targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like a malignant growth, diabetes, cardiovascular and neurodegenerative. The current review deals with the antioxidant property of ferulic acid and the recent patent describe the role of ferulic acid against human diseases. PMID: 31223096 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Publication date: Available online 21 June 2019Source: Journal of BiotechnologyAuthor(s): Chen Zhang, Ying Zang, Peng Liu, Zhaojuan Zheng, Jia OuyangAbstract4-Coumarate: CoA ligase (4CL) is an important branch point directing metabolites to flavonoid or monolignol pathways in plants. It plays a vital role in the biosynthesis of plant nature products in microbes. Herein, Ptr4CL4, Ptr4CL5 and Ptr4CL7 from Populus trichocarpa were cloned and expressed in Escherichia coli. Two recombinant proteins Ptr4CL4 and Ptr4CL5 showed distinct activities for different substrates. The Ptr4CL4, not previously reported, showed the hi...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
In this study, we prepared Zn/Al-Cl LDH with different Zn:Al molar ratios for immobilization of the lipase from Pseudomonas cepacia. The best values for activity retention (188%), immobilization efficiency (96%) and hydrolytic activity in organic medium (279 U g-1) were obtained with a molar ratio of Zn:Al of 4:1, a protein loading of 162 mg g-1 and Tris-HCl buffer (10 mmol L-1, pH 7.5) as the solvent for preparing the lipase solution. The immobilized lipase keeps its activity when stored at 4 °C during 30 days. The immobilized lipase gave a conversion of 50% in 1 h for the kinetic re...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
Publication date: Available online 22 June 2019Source: Computational and Structural Biotechnology JournalAuthor(s): S. Lu, J. Qian, M. Guo, C. Gu, Y. YangAbstractThyroid Hormone Receptor Interacting Protein 13 (TRIP13) plays a key role in regulating mitotic processes, including spindle assembly checkpoint and DNA repair pathways, which may account for Chromosome instability (CIN). As CIN is a predominant hallmark of cancer, TRIP13 may act as a tumor susceptibility locus. Amplification of TRIP13 has been observed in various human cancers and implicated in several aspects of malignant transformation, including cancer cell pr...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: Available online 22 June 2019Source: Biosensors and BioelectronicsAuthor(s): Hui-Fang Cui, Ting-Ting Zhang, Qi-Yan Lv, Xiaojie Song, Xiao-Jing Zhai, Gai-Gai WangAbstractA stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. AuNRs@MS core-shell nanoparticles were synthesized and characterized. The doping and the biosensor fabrication process were probed and confirmed by scanning ele...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 21 June 2019Source: Biosensors and BioelectronicsAuthor(s): Jianping Li, Nen Wan, Jianming Wen, Guangming Cheng, Lidong He, Li ChengAbstractThrombus formation is quantitatively measured and evaluated by the electrical impedance spectroscopy method in this study, which confirms the possibility for the application of a promising non-invasive thrombus detection method. The impedance parameter Z*(t) of blood from the electrical impedance spectroscopy is utilized to elaborate the impedance performance of blood during thrombus formation process. Experimental results indicate that the impedance ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 21 June 2019Source: Biosensors and BioelectronicsAuthor(s): Jinru Zhou, Qinqin Qi, Chong Wang, Yifan Qian, Guangming Liu, Yanbo Wang, Linglin FuAbstractFood allergies are recognized as a growing public health concern, with an estimated 3% of adults and 6-8% of children affected by food allergy disorders. Hence, food allergen detection, labeling, and management have become significant priorities within the food industry, and there is an urgent requirement for reliable, sensitive, and user-friendly technologies to trace food allergens in food products. In this critical review, we provide a ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 21 June 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Karthik Rajendran, Ganti S. MurthyAbstractTechno-economic analysis and life cycle assessments are crucial for any processes to be sustainable using the tri-fold metrics including technical feasibility, economic viability, and environmental sustainability. Anaerobic digestion is portrayed as one of the mature technologies for handling solid waste management and bioenergy generation. Nonetheless, a clear assessment of the tri-fold sustainability metrics is not available yet and this review attempts to address this kno...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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