Determination of genotoxic potencies of pyrrolizidine alkaloids in HepaRG cells using the γH2AX assay.

This study reveals differences in in vitro genotoxic potencies of PAs, supporting that the assumption that all PAs have a similar potency as riddelliine is rather conservative. PMID: 31154085 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31154085?dopt=Abstract

Source: Food and Chemical Toxicology - May 29, 2019 Category: Food Science Authors: Louisse J, Rijkers D, Stoopen G, Holleboom WJ, Delagrange M, Molthof E, Mulder PPJ, Hoogenboom RLAP, Audebert M, Peijnenburg AACM Tags: Food Chem Toxicol Source Type: research