David E. Barmes Global Health Lecture: Global Health in a Changing World
The National Institute of Dental and Craniofacial Research (NIDCR) and the Fogarty International Center present the 2019 David E. Barmes Global Health Lecture: “ Global Health in a Changing World, ” presented by Wellcome Trust Director Dr. Jeremy Farrar. A world-renowned clinical scientist and leading figure in the field of infectious disease, Dr. Jeremy Farrar has been Director of the Wellcome Trust since 2013. Wellcome is an independent foundation with a $33 billion investment portfolio that offers grants across biomedical science, population health, medical innovation, humanities and social science, and public engagement. It supports the work of over 14,000 researchers in about 100 countries. Previously, for 18 years Farrar was Director of the Oxford University Clinical Research Unit in Vietnam, which is supported by Wellcome. His research interests were infectious diseases, tropical health and emerging infections. Farrar recently received the 2019 Jimmy and Rosalynn Carter Humanitarian Award from the National Foundation for Infectious Diseases. He was named 12th in Fortune's list of the World's 50 Greatest Leaders in 2015. His other awards include the Order of the British Empire in 2005 for services to tropical medicine, as well as the Memorial Medal and the Ho Chi Minh City Medal by the Government of Vietnam. He is a Fellow of both the Academy of Medical Sciences and the Royal Society. The David E. Barmes Global Health Lecture series honors the late David Edw...
CONCLUSION: Prevalence of antibiotic use was high not only versus other hospitals in the region but globally including Africa, coupled with significant evidence of sub-optimal prescribing. Swift action is needed to improve future prescribing to reduce AMR. One or two areas should initially be targeted for quality improvement including development of local guidelines, documentation of antibiotic indications and/or stop/review dates. PMID: 33034234 [PubMed - as supplied by publisher]
Authors: Rombauts A, Abelenda-Alonso G, Cuervo G, Gudiol C, Carratalà J Abstract INTRODUCTION: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant in severe cases. The intensity of the dysregulated host response varies from patient to patient and has a negative impact on survival and other outcomes. AREAS COVERED: This comprehensive review summarizes the pathophysiological aspects of the inflammatory response in CAP, brie...
Authors: Hammerschlag MR, Sharma R Abstract INTRODUCTION: Azithromycin was recommended as the first-line therapeutic regimen for treatment of genital infections in men and women by the Centers for Disease Control in 1998. A series of studies of azithromycin for treatment of rectal chlamydial infection in men who have sex with men (MSM) found that azithromycin was significantly less effective than doxycycline. AREAS COVERED: Literature on treatment of rectal C. trachomatis from 2000 through May 2020 was searched using PubMed. Retrospective and observational studies were identified documenting the frequency and t...
Authors: Reissier S, Cattoir V Abstract INTRODUCTION: Streptogramins (pristinamycin and quinupristin-dalfopristin) can be interesting options for the treatment of infections due to Gram-positive cocci, especially multidrug-resistant isolates. AREAS COVERED: This review provides an updated overview on structural and activity characteristics, mechanisms of action and resistance, pharmacokinetic/pharmacodynamic and clinical use of streptogramins. EXPERT OPINION: The streptogramin antibiotics act by inhibition of the bacterial protein synthesis. They are composed of two chemically distinct compounds, namely typ...
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