MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

Chronic hepatitis B virus (HBV) infection continues to be a major public health burden worldwide. The persistence of HBV infection increases the risk of end-stage liver diseases, such as liver cirrhosis and hepatocellular carcinoma[1]. Exposure to HBV in neonates usually leads to viral persistence, whereas most infected adults spontaneously clear the virus[2]. The clearance of HBV relies largely on a potent and diverse T cell immune response, which usually becomes dysregulated in chronic HBV infection[3 –5].

Source: Journal of Hepatology - June 3, 2019 Category: Gastroenterology Authors: Shangqing Yang, Lu Wang, Wen Pan, Wibke Bayer, Christine Thoens, Kathrin Heim, Ulf Dittmer, Joerg Timm, Qin Wang, Qing Yu, Jinzhuo Luo, Yanan Liu, Maike Hofmann, Robert Thimme, Xiaoyong Zhang, Hongtao Chen, Hua Wang, Xuemei Feng, Xuecheng Yang, Yinping Lu Source Type: research